肾移植患者的肾酶基因多态性
Renalase gene polymorphism in patients after renal allograft transplantation.
作者信息
Pawlik Andrzej, Serdynska Maria, Dabrowska-Zamojcin Ewa, Dziedziejko Violetta, Safranow Krzysztof, Domanski Leszek, Ciechanowski Kazimierz
机构信息
Department of Pharmacology, Pomeranian Medical University, Szczecin, Poland.
出版信息
Kidney Blood Press Res. 2014;39(1):58-64. doi: 10.1159/000355777. Epub 2014 Jun 3.
BACKGROUND/AIMS: Renalase is a recently discovered protein, which is likely involved in regulation of blood pressure in humans and animals. Previous studies suggest that renalase reflects kidney functioning. A common missense polymorphism in the flavin-adenine dinucleotide-binding domain of human renalase (Glu37Asp) has been described. In this study we examined the association between (Glu37Asp) polymorphism (rs2296545) in renalase gene and kidney allograft function.
METHODS
The study enrolled 270 Caucasian kidney allograft recipients. SNP within the renalase was genotyped using TaqMan genotyping assays.
RESULTS
There were no statistically significant associations between renalase gene rs2296545 polymorphism and delayed graft function, acute rejection, chronic allograft dysfunction as well as creatinine serum concentrations and blood pressure values after transplantation.
CONCLUSIONS
The results of this study suggest, that renalase gene rs2296545 polymorphism is not important factor determining renal allograft function.
背景/目的：肾酶是一种最近发现的蛋白质，可能参与人和动物的血压调节。先前的研究表明肾酶反映肾脏功能。已描述了人类肾酶黄素腺嘌呤二核苷酸结合域中的一种常见错义多态性（Glu37Asp）。在本研究中，我们检测了肾酶基因中的（Glu37Asp）多态性（rs2296545）与肾移植功能之间的关联。
方法
该研究纳入了270名白种人肾移植受者。使用TaqMan基因分型检测法对肾酶内的单核苷酸多态性进行基因分型。
结果
肾酶基因rs2296545多态性与移植肾功能延迟、急性排斥反应、慢性移植肾功能障碍以及移植后血清肌酐浓度和血压值之间无统计学显著关联。
结论
本研究结果表明，肾酶基因rs2296545多态性不是决定肾移植功能的重要因素。
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