Sharaby Israa, Alksas Ahmed, Abou El-Ghar Mohamed, Eldeeb Mona, Ghazal Mohammed, Gondim Dibson, El-Baz Ayman
Bioengineering Department, University of Louisville, Louisville, KY 40292, USA.
Radiology Department, Urology and Nephrology Center, Mansoura University, Mansoura 35516, Egypt.
Biomedicines. 2023 Aug 31;11(9):2437. doi: 10.3390/biomedicines11092437.
Kidney transplantation is the preferred treatment for end-stage renal failure, but the limited availability of donors and the risk of immune rejection pose significant challenges. Early detection of acute renal rejection is a critical step to increasing the lifespan of the transplanted kidney. Investigating the clinical, genetic, and histopathological markers correlated to acute renal rejection, as well as finding noninvasive markers for early detection, is urgently needed. It is also crucial to identify which markers are associated with different types of acute renal rejection to manage treatment effectively. This short review summarizes recent studies that investigated various markers, including genomics, histopathology, and clinical markers, to differentiate between different types of acute kidney rejection. Our review identifies the markers that can aid in the early detection of acute renal rejection, potentially leading to better treatment and prognosis for renal-transplant patients.
肾移植是终末期肾衰竭的首选治疗方法，但供体的有限可用性和免疫排斥风险带来了重大挑战。急性肾排斥的早期检测是延长移植肾寿命的关键步骤。迫切需要研究与急性肾排斥相关的临床、遗传和组织病理学标志物，以及寻找早期检测的非侵入性标志物。识别哪些标志物与不同类型的急性肾排斥相关，以有效管理治疗也至关重要。这篇简短的综述总结了最近的研究，这些研究调查了各种标志物，包括基因组学、组织病理学和临床标志物，以区分不同类型的急性肾排斥。我们的综述确定了有助于急性肾排斥早期检测的标志物，这可能会为肾移植患者带来更好的治疗和预后。
