Tuna Mazhar Müslüm, Imga Narin Nasıroğlu, Doğan Berçem Ayçiçek, Yılmaz Fatma Meriç, Topçuoğlu Canan, Akbaba Gülhan, Berker Dilek, Güler Serdar
Endocrinology and Metabolism Division, Medical Faculty, Dicle University, Diyarbakır, Turkey.
Endocrinology and Metabolism Division, Ankara Numune Training and Research Hospital, Ankara, Turkey.
J Endocrinol Invest. 2014 Aug;37(8):765-768. doi: 10.1007/s40618-014-0106-5. Epub 2014 Jun 13.
Adrenal incidentalomas (AIs) have been associated with an increased incidence of several cardiovascular risk factors. The aim of this study was to investigate plasma adiponectin, leptin, resistin, homocysteine, high sensitive C-reactive protein levels, and carotid intima media thickness (CIMT) in patients with non-functioning AI (NFAI).
This study included data from 28 patients with NFAI (Group 1) and 41 controls (Group 2). Of the patients, 50 were female and 19 were male, and the mean age was 46.7 (range 37-65) years.
There were no significant differences between Group 1 and 2 in terms of age, sex, or BMI. Hypertension prevalence was significantly higher in the NFAI group than in the control group (p = 0.01). Both groups had similar lipid, blood glucose, homocysteine, uric acid, high-sensitivity CRP levels. Adiponectin, leptin, and resistin levels were similar in both groups. CIMTs were significantly higher in the NFAI group.
There is increasing evidence that several cardiometabolic risk factors occur with higher prevalence in non-functioning adrenal incidentaloma patients compared to age-matched healthy subjects. In our study, hypertension prevalence and CIMT were higher in the NFAI group. Serum adipokine levels were similar for both groups.
肾上腺偶发瘤（AIs）与多种心血管危险因素的发生率增加有关。本研究的目的是调查无功能肾上腺偶发瘤（NFAI）患者的血浆脂联素、瘦素、抵抗素、同型半胱氨酸、高敏C反应蛋白水平以及颈动脉内膜中层厚度（CIMT）。
本研究纳入了28例NFAI患者（第1组）和41例对照者（第2组）的数据。患者中，50例为女性，19例为男性，平均年龄为46.7岁（范围37 - 65岁）。
第1组和第2组在年龄、性别或体重指数方面无显著差异。NFAI组的高血压患病率显著高于对照组（p = 0.01）。两组的血脂、血糖、同型半胱氨酸、尿酸、高敏CRP水平相似。两组的脂联素、瘦素和抵抗素水平相似。NFAI组的CIMT显著更高。
越来越多的证据表明，与年龄匹配的健康受试者相比，无功能肾上腺偶发瘤患者中几种心脏代谢危险因素的患病率更高。在我们的研究中，NFAI组的高血压患病率和CIMT更高。两组的血清脂肪因子水平相似。
