微创牙科：第8部分。牙髓的生物疗法。

Minimal intervention dentistry: part 8. Biotherapies for the dental pulp.

作者信息

Chaussain C, Poliard A

机构信息

1] EA 2496, Pathologies et Biothérapies de la Dent, UFR Odontologie Paris Descartes, PRES Sorbonne Paris Cité, Montrouge, France-92120 [2] Service Odontologie Bretonneau, AP-HP, France-75018.

EA 2496, Pathologies et Biothérapies de la Dent, UFR Odontologie Paris Descartes, PRES Sorbonne Paris Cité, Montrouge, France-92120.

出版信息

Br Dent J. 2014 Jun 13;216(11):619-21. doi: 10.1038/sj.bdj.2014.450.

DOI:10.1038/sj.bdj.2014.450

PMID:24923934

Abstract

The development of new therapies, the biotherapies, can now be envisioned in dentistry thanks to the important development of research in the stem cell and biomaterial fields. Indeed, the recent discovery of stem cells in different tissues of the body, and in particular in the dental pulp, should allow the development of new therapeutic approaches for pulpo-dentinal lesions. In case of moderate pulp injury, the stimulation by biomolecules of pulp stem cells located in the remaining pulp is the approach to be considered. In case of more severe lesions requiring a total removal of pulp tissues, a cell therapy could be considered. The objective of this article is to present these innovative therapeutic approaches for the future of dentistry.

摘要

由于干细胞和生物材料领域研究的重大进展，如今在牙科领域可以设想新型疗法即生物疗法的发展。事实上，最近在身体不同组织，尤其是牙髓中发现干细胞，这应该能够为牙髓-牙本质病变开发新的治疗方法。对于中度牙髓损伤，可考虑通过生物分子刺激位于剩余牙髓中的牙髓干细胞。对于需要完全去除牙髓组织的更严重病变，可考虑细胞疗法。本文的目的是介绍这些牙科未来的创新治疗方法。