Department of Orthopaedic Oncology, MD Anderson Cancer Center, 301402, Unit 1448, Houston, TX, 77230-1402, USA,
Adv Exp Med Biol. 2014;804:285-9. doi: 10.1007/978-3-319-04843-7_15.
Recent advances have shown that cell surface receptors are expressed differentially in normal and pathological conditions. Novel organ specific and disease specific proteins expressed on tumor vasculature have been identified by in vivo phage display technology and the diversity of the tumor-associated vasculature has provided the basis for the development of targeted therapeutics. Investigators recently screened a phage display library in a human cancer patient. An IL-11 mimic phage displaying the cyclic peptide CGRRAGGSC (single letter amino acid code) specifically bound to immobilized IL-11Rα. It has been demonstrated that the expression of the IL-11Rα is increased in several other types of tumors including osteosarcoma. The ability to selectively target the IL-11Rα may provide an alternative treatment of for a disease where new treatment options are truly needed.
最近的进展表明，细胞表面受体在正常和病理条件下表达不同。通过体内噬菌体展示技术鉴定了在肿瘤血管中表达的新型器官特异性和疾病特异性蛋白，而肿瘤相关血管的多样性为靶向治疗的发展提供了基础。研究人员最近在一名癌症患者中筛选了噬菌体展示文库。一种展示环状肽 CGRRAGGSC（单字母氨基酸代码）的 IL-11 模拟噬菌体特异性结合固定化的 IL-11Rα。已经证明，IL-11Rα的表达在包括骨肉瘤在内的几种其他类型的肿瘤中增加。选择性靶向 IL-11Rα 的能力可能为真正需要新治疗选择的疾病提供替代治疗方法。
