Norris T, Cameron N
1 Centre for Global Health and Human Development, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
2 Human Sciences, Loughborough University, Loughborough, UK.
J Dev Orig Health Dis. 2013 Dec;4(6):434-41. doi: 10.1017/S2040174413000251.
Theories regarding the relationship between pre- and postnatal growth and programming of health have been based on characteristics at birth, with little or no reference to the patterns of growth occurring in utero. Review of the literature to identify studies using ultrasonographically obtained fetal dimensions to track prenatal growth and relate these patterns of growth to postnatal anthropometry and cardiovascular and metabolic risk factors. Review of Medline, Scopus and Proquest for studies reporting on ultrasonographically derived estimates of fetal growth and their association with postnatal anthropometry, body composition or cardiovascular and metabolic risk factors. Quality of papers were assessed using the method developed by Downs and Black. Twenty-nine studies met the inclusion criteria, with a mean score of high quality. Twenty of the studies had follow-up in infancy, five in childhood, three in adolescence and one in adulthood. The associations observed suggest that centile tracking may occur early in pregnancy though whether this is as early as the first trimester is uncertain. The second trimester may be a critical period for the programming of blood pressure and abdominal circumference may be the most sensitive fetal dimension to indicate any programming.
关于出生前和出生后生长与健康编程之间关系的理论一直基于出生时的特征，很少或根本没有提及子宫内发生的生长模式。回顾文献以确定使用超声获得的胎儿尺寸来追踪产前生长，并将这些生长模式与出生后人体测量学以及心血管和代谢风险因素相关联的研究。检索Medline、Scopus和Proquest，查找报告超声得出的胎儿生长估计值及其与出生后人体测量学、身体成分或心血管和代谢风险因素关联的研究。使用Downs和Black开发的方法评估论文质量。29项研究符合纳入标准，平均质量得分较高。其中20项研究在婴儿期进行了随访，5项在儿童期，3项在青春期，1项在成年期。观察到的关联表明，百分位数追踪可能在妊娠早期就已出现，不过是否早在孕早期尚不确定。孕中期可能是血压编程的关键时期，腹围可能是指示任何编程的最敏感胎儿尺寸。
