Bouchon R, Misslin R, Vogel E, Ropartz P
Laboratoire de Psychophysiologie, 7 rue de l'Université. F- 67000 Strasbourg, France.
Behav Processes. 1987 Dec;15(2-3):155-65. doi: 10.1016/0376-6357(87)90004-0.
The effects of ectopic pituitary isografts on response to novelty were studied in adult Snell Dwarf mice. Because of anterohypophyseal deficiency, these animals exhibit dwarfism, sterility and marked neurochemical and behavioural deficits. When given the opportunity to move around freely in simultaneously presented novel and familiar environments, grafted dwarf (GRAFT Dw) and sham-grafted control (SHAM C) mice showed a significant novelty preference while sham-grafted dwarf (SHAM Dw) mice exhibited no preference. Both SHAM C and GRAFT Dw mice frequently reared and covered the familiar compartment more quickly than the novel compartment, while SHAM Dw mice reared infrequently and covered the two compartments at equal speed. These data reveal in the mutant a total indifference toward its environment and show a total recovery of neotic behaviour after grafting. The literature is very vague concerning the hormonal changes induced after ectopic pituitary grafting but subsequent specific hormonal treatments and biochemical manipulations would facilitate identification of the hypophyseal hormones and/or the growth factors involved in the behavioural changes.
研究了异位垂体同基因移植对成年斯奈尔侏儒小鼠新奇反应的影响。由于垂体前叶功能不足，这些动物表现出侏儒症、不育以及明显的神经化学和行为缺陷。当有机会在同时呈现的新奇和熟悉环境中自由活动时，移植侏儒（GRAFT Dw）小鼠和假移植对照（SHAM C）小鼠表现出显著的新奇偏好，而假移植侏儒（SHAM Dw）小鼠则无偏好。SHAM C小鼠和GRAFT Dw小鼠都频繁站立，并比新奇区域更快地覆盖熟悉区域，而SHAM Dw小鼠很少站立，且以相同速度覆盖两个区域。这些数据揭示，突变体对其环境完全漠不关心，且移植后新生物行为完全恢复。关于异位垂体移植后引起的激素变化，文献记载非常模糊，但随后的特定激素治疗和生化操作将有助于确定参与行为变化的垂体激素和/或生长因子。
