Bouchon R, Ropartz P
Physiol Behav. 1986;36(4):597-602. doi: 10.1016/0031-9384(86)90340-9.
The effects of ectopic pituitary homografts on free behavior were studied over a period of one month in adult Snell Dwarf mice. Because of anterohypophyseal deficiency, these animals exhibit dwarfism, sterility, and marked behavioral deficits. Beginning on the 16th day after surgery, in addition to a considerable weight gain, grafts result in the total disappearance of inactivity with passive social contact--the behavior most frequently observed in the mutants--to be replaced only by exploration--the most frequently observed behavior in controls. The treatment totally restores the latter behavior. Specific hormonal treatments and biochemical manipulations at different stages would enable identification of the hypophyseal hormones and/or the growth factors involved in the behavioral and morphological changes.
在成年斯奈尔侏儒小鼠中，对异位垂体同种移植对自由行为的影响进行了为期一个月的研究。由于垂体前叶功能不足，这些动物表现出侏儒症、不育和明显的行为缺陷。从手术后第16天开始，除了体重显著增加外，移植导致被动社交接触时的不活动行为完全消失（这种行为在突变体中最常观察到），仅被探索行为取代（探索行为是对照组中最常观察到的行为）。这种治疗完全恢复了后一种行为。在不同阶段进行特定的激素治疗和生化操作，将能够识别参与行为和形态变化的垂体激素和/或生长因子。
