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左乙拉西坦抑制皮质基底节变性的肌阵挛。

Suppression of myoclonus in corticobasal degeneration by levetiracetam.

机构信息

Department of Neurology, Pusan National University Yangsan Hospital, Yangsan, Korea.

出版信息

J Mov Disord. 2014 Apr;7(1):28-30. doi: 10.14802/jmd.14007. Epub 2014 Apr 30.

DOI:10.14802/jmd.14007
PMID:24926409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4051726/
Abstract

Myoclonus in corticobasal degeneration (CBD) has often been associated with severe and difficult to treat disabilities. Levetiracetam is a new antiepileptic agent with antimyoclonic effects. Herein, we present a 72-year-old woman with clinically probable CBD and with spontaneous rhythmic myoclonus in the right foot, which was markedly ameliorated through treatment with levetiracetam. The effect of levetiracetam was associated with the decreased amplitude of enlarged cortical somatosensory evoked potentials. This result suggests that the antimyoclonic effect of levetiracetam might be mediated through the suppression of increased cortical excitability.

摘要

皮质基底节变性（CBD）中的肌阵挛常与严重且难以治疗的残疾相关。左乙拉西坦是一种具有抗肌阵挛作用的新型抗癫痫药物。本文报道了一例临床可能的 CBD 患者，其右脚出现自发性节律性肌阵挛，左乙拉西坦治疗后明显改善。左乙拉西坦的疗效与扩大的皮质体感诱发电位幅度的降低有关。这一结果表明，左乙拉西坦的抗肌阵挛作用可能是通过抑制皮质兴奋性的增加来介导的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1ce/4051726/7f43fe5e8f34/jmd-7-1-28-7f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1ce/4051726/7f43fe5e8f34/jmd-7-1-28-7f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1ce/4051726/7f43fe5e8f34/jmd-7-1-28-7f1.jpg

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2
Effect of levetiracetam on cortical excitability: a transcranial magnetic stimulation study.左乙拉西坦对皮质兴奋性的影响：一项经颅磁刺激研究。
Eur J Neurol. 2008 May;15(5):501-5. doi: 10.1111/j.1468-1331.2008.02110.x.
3
Parkinsonism & related disorders. Myoclonus.帕金森综合征及相关疾病。肌阵挛。
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Mov Disord Clin Pract. 2016 Jan 29;3(4):417-420. doi: 10.1002/mdc3.12259. eCollection 2016 Jul-Aug.
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