Alausa Abdullahi, Ogundepo Sunday, Olaleke Barakat, Adeyemi Rofiat, Olatinwo Mercy, Ismail Aminat
Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo, Nigeria.
Department of Science Laboratory Technology, Faculty of Pure & Applied Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo, Nigeria.
Chin Med. 2021 Jan 6;16(1):1. doi: 10.1186/s13020-020-00418-7.
The onset of neurodegenerative disease has not only been a major cause of scientific worry, but of economic burden to the health system. This condition has been further attributed to mis-stability, deletion or mutation of tau protein, causing the onset of Corticobasal degeneration, Pick's diseases, Progressive supranuclear palsy, Argyrophilic grains disease, Alzheimer's diseases etc. as scientifically renowned. This is mainly related to dysregulation of translational machinery, upregulation of proinflammatory cytokines and inhibition of several essential cascades such as ERK signaling cascade, GSK3β, CREB, and PKA/PKB (Akt) signaling cascades that enhances protein processing, normal protein folding, cognitive function, and microtubule associated tau stability. Administration of some nutrients and/or bioactive compounds has a high tendency to impede tau mediated inflammation at neuronal level. Furthermore, prevention and neutralization of protein misfolding through modulation of microtubule tau stability and prevention of protein misfolding is by virtue few of the numerous beneficial effects of physical activity. Of utmost important in this study is the exploration of promising bioactivities of nutraceuticals found in china and the ameliorating potential of physical activity on tauopathies, while highlighting animal and in vitro studies that have been investigated for comprehensive understanding of its potential and an insight into the effects on human highly probable to tau mediated neurodegeneration.
神经退行性疾病的发作不仅一直是科学领域担忧的主要原因，也是卫生系统的经济负担。这种情况进一步归因于tau蛋白的错误稳定性、缺失或突变，导致皮质基底节变性、匹克氏病、进行性核上性麻痹、嗜银颗粒病、阿尔茨海默病等疾病的发作，这些都是科学界所熟知的。这主要与翻译机制的失调、促炎细胞因子的上调以及对几种重要级联反应的抑制有关，如ERK信号级联、GSK3β、CREB和PKA/PKB（Akt）信号级联，这些级联反应可增强蛋白质加工、正常蛋白质折叠、认知功能以及与微管相关的tau稳定性。施用某些营养素和/或生物活性化合物很有可能在神经元水平上抑制tau介导的炎症。此外，通过调节微管tau稳定性和防止蛋白质错误折叠来预防和中和蛋白质错误折叠是体育活动众多有益作用中的一部分。在这项研究中，最重要的是探索在中国发现的营养保健品的潜在生物活性以及体育活动对tau蛋白病的改善潜力，同时强调已进行的动物和体外研究，以便全面了解其潜力并深入了解其对极有可能发生tau介导神经退行性变的人类的影响。
