Jeong Tae-Seok, Yee Gi-Taek
Department of Neurosurgery, Gil Medical Center, Gachon University, Incheon, Korea.
Brain Tumor Res Treat. 2014 Apr;2(1):36-8. doi: 10.14791/btrt.2014.2.1.36. Epub 2014 Apr 29.
Neurofibromatosis type 1 (NF1) is an autosomal dominantly inherited familial tumor syndrome. Benign tumors such as pilocytic astrocytoma, optic glioma make up the majority of intracranial neoplasms in patients with NF1. There have only been a handful of cases in which adult glioblastoma presented with NF1. A 32-year-old male presented with headache and radiological studies showing a high grade intra-axial tumor. The patient underwent gross total surgical excision and the pathology revealed glioblastoma. After the surgery, he received concomitant chemo-radiotherapy with temozolomide and adjuvant temozolomide chemotherapy. We report a NF1 patient who developed glioblastoma and reviewed related articles.
1型神经纤维瘤病（NF1）是一种常染色体显性遗传的家族性肿瘤综合征。良性肿瘤如毛细胞型星形细胞瘤、视神经胶质瘤构成了NF1患者颅内肿瘤的大部分。仅有少数成胶质细胞瘤患者伴有NF1的病例报道。一名32岁男性因头痛就诊，影像学检查显示轴内高级别肿瘤。该患者接受了肿瘤全切手术，病理检查显示为成胶质细胞瘤。术后，他接受了替莫唑胺同步放化疗及辅助化疗。我们报告了一例发生成胶质细胞瘤的NF1患者并回顾了相关文献。
