• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

1型神经纤维瘤病患者的多形性胶质母细胞瘤：病例报告及文献复习

Glioblastoma multiforme in a patient with neurofibromatosis type 1: a case report and review of literature.

作者信息

Ayasa Laith A, Rahhal Sara, Najjar Alaa Khaled, Suboh Bashar N, Aliwaiai Mohammed, Daqour Ahmad M, Bakri Izzeddin

机构信息

Al Quds University Faculty of Medicine, Mount of Olives St. 26, Sheikh Jarrah, P.O. Box 22246, Jerusalem 91513, Palestine.

School of Medicine, The University of Jordan, Amman, Queen Rania St. Jubeiha, P.O. Box 11942, Amman, Jordan.

出版信息

J Surg Case Rep. 2024 Aug 28;2024(8):rjae517. doi: 10.1093/jscr/rjae517. eCollection 2024 Aug.

DOI:10.1093/jscr/rjae517
PMID:39211378
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11358049/
Abstract

Glioblastoma multiforme (GBM) is a highly aggressive brain tumor. Individuals with neurofibromatosis type 1 (NF1) have an increased risk of developing GBM. We present a case report of a 44-year-old male with NF1 who developed GBM. NF1-associated GBM presents distinct molecular features and younger age at diagnosis compared to sporadic cases. Treatment typically follows standard protocols for GBM. Despite advancements in neuro-oncology, gaps in knowledge persist regarding NF1-associated GBM, including its prevalence, molecular mechanisms, and optimal treatment strategies. Larger studies and collaborative efforts are needed to address these gaps and enhance patient care.

摘要

多形性胶质母细胞瘤（GBM）是一种高度侵袭性的脑肿瘤。患有1型神经纤维瘤病（NF1）的个体患GBM的风险增加。我们报告一例44岁患有NF1并发生GBM的男性病例。与散发性病例相比，NF1相关的GBM具有独特的分子特征且诊断时年龄较小。治疗通常遵循GBM的标准方案。尽管神经肿瘤学取得了进展，但关于NF1相关GBM的知识仍存在空白，包括其患病率、分子机制和最佳治疗策略。需要开展更大规模的研究和合作努力来填补这些空白并改善患者护理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf66/11358049/f99dd137a11f/rjae517f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf66/11358049/6dbb6a0bf061/rjae517f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf66/11358049/78100fe5857e/rjae517f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf66/11358049/773ede33418f/rjae517f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf66/11358049/f99dd137a11f/rjae517f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf66/11358049/6dbb6a0bf061/rjae517f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf66/11358049/78100fe5857e/rjae517f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf66/11358049/773ede33418f/rjae517f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf66/11358049/f99dd137a11f/rjae517f4.jpg

相似文献

1
Glioblastoma multiforme in a patient with neurofibromatosis type 1: a case report and review of literature.1型神经纤维瘤病患者的多形性胶质母细胞瘤：病例报告及文献复习
J Surg Case Rep. 2024 Aug 28;2024(8):rjae517. doi: 10.1093/jscr/rjae517. eCollection 2024 Aug.
2
Brainstem Glioblastoma Multiforme in a Patient with NF1.1型神经纤维瘤病患者的脑干多形性胶质母细胞瘤
Anticancer Res. 2018 Aug;38(8):4897-4900. doi: 10.21873/anticanres.12804.
3
Papillary thyroid carcinoma associated with glioblastoma in a neurofibromatosis 1 patient: An unusual and rare combination of multiple primary malignancies.1型神经纤维瘤病患者中甲状腺乳头状癌与胶质母细胞瘤并存：一种罕见的多原发性恶性肿瘤组合。
Ann Med Surg (Lond). 2022 Mar 28;76:103556. doi: 10.1016/j.amsu.2022.103556. eCollection 2022 Apr.
4
Cerebellar glioblastoma in an NF1 patient. Is it surgical debulking really necessary?NF1 患者的小脑胶质母细胞瘤。真的有必要进行手术切除吗？
Br J Neurosurg. 2020 Dec;34(6):669-671. doi: 10.1080/02688697.2019.1690127. Epub 2019 Nov 20.
5
Schweinfurthin A selectively inhibits proliferation and Rho signaling in glioma and neurofibromatosis type 1 tumor cells in a NF1-GRD-dependent manner.施魏因富特辛 A 以 NF1-GRD 依赖的方式选择性地抑制神经胶质瘤和神经纤维瘤病 1 型肿瘤细胞的增殖和 Rho 信号通路。
Mol Cancer Ther. 2010 May;9(5):1234-43. doi: 10.1158/1535-7163.MCT-09-0834. Epub 2010 May 4.
6
Fatal glioblastoma multiforme in a patient with neurofibromatosis type I: the dilemma of systematic medical follow-up.一名患有I型神经纤维瘤病的患者发生致命性多形性胶质母细胞瘤：系统性医学随访的困境
Childs Nerv Syst. 2007 Mar;23(3):343-7. doi: 10.1007/s00381-006-0222-4. Epub 2006 Aug 29.
7
Glioblastoma in a patient with neurofibromatosis type 1: a case report and review of the literature.1型神经纤维瘤病患者的胶质母细胞瘤：一例病例报告及文献综述
Brain Tumor Res Treat. 2014 Apr;2(1):36-8. doi: 10.14791/btrt.2014.2.1.36. Epub 2014 Apr 29.
8
Ccl5 establishes an autocrine high-grade glioma growth regulatory circuit critical for mesenchymal glioblastoma survival.趋化因子配体5（Ccl5）建立了一个自分泌的高级别胶质瘤生长调节回路，该回路对间充质胶质母细胞瘤的存活至关重要。
Oncotarget. 2017 May 16;8(20):32977-32989. doi: 10.18632/oncotarget.16516.
9
Clinicopathological and Immunohistochemistry Study of a Long Survivor of Giant Cell Glioblastoma in a Patient With Neurofibromatosis 1: Case Report.1型神经纤维瘤病患者巨大细胞胶质母细胞瘤长期存活者的临床病理及免疫组化研究：病例报告
Cureus. 2023 May 14;15(5):e39014. doi: 10.7759/cureus.39014. eCollection 2023 May.
10
Temozolomide (TMZ) in the Treatment of Glioblastoma Multiforme-A Literature Review and Clinical Outcomes.替莫唑胺（TMZ）治疗多形性胶质母细胞瘤：文献回顾与临床结局。
Curr Oncol. 2024 Jul 12;31(7):3994-4002. doi: 10.3390/curroncol31070296.

本文引用的文献

1
Ten-year survival in glioblastoma patient with neurofibromatosis type 1: illustrative case.1型神经纤维瘤病胶质母细胞瘤患者的10年生存率：病例说明
J Neurosurg Case Lessons. 2022 Jan 24;3(4). doi: 10.3171/CASE21630.
2
Gene Alterations Define Specific Features of a Subset of Glioblastomas.基因突变定义了一部分胶质母细胞瘤的特定特征。
Int J Mol Sci. 2021 Dec 29;23(1):352. doi: 10.3390/ijms23010352.
3
Glioblastoma in a female neurofibromatosis 1 patient without IDH1, BRAF V600E, and TERT promoter mutations: A case report.女性神经纤维瘤病 1 型患者的胶质母细胞瘤，无 IDH1、BRAF V600E 和 TERT 启动子突变：病例报告。
Medicine (Baltimore). 2021 Apr 2;100(13):e25346. doi: 10.1097/MD.0000000000025346.
4
Glioblastoma in adults with neurofibromatosis type I: A report of two cases.成人 I 型神经纤维瘤病合并胶质母细胞瘤：两例报告
Neuropathology. 2019 Oct;39(5):368-373. doi: 10.1111/neup.12579. Epub 2019 Aug 21.
5
The molecular landscape of glioma in patients with Neurofibromatosis 1.神经纤维瘤病 1 型患者的胶质瘤分子图谱。
Nat Med. 2019 Jan;25(1):176-187. doi: 10.1038/s41591-018-0263-8. Epub 2018 Dec 10.
6
Glioblastoma Multiforme, Diagnosis and Treatment; Recent Literature Review.多形性胶质母细胞瘤：诊断与治疗；近期文献综述
Curr Med Chem. 2017;24(27):3002-3009. doi: 10.2174/0929867324666170516123206.
7
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.胶质瘤亚型的全基因组关联研究揭示了胶质母细胞瘤和非胶质母细胞瘤肿瘤在遗传易感性方面的特定差异。
Nat Genet. 2017 May;49(5):789-794. doi: 10.1038/ng.3823. Epub 2017 Mar 27.
8
A rare case of neurofibromatosis - type 1.1型神经纤维瘤病1例罕见病例。
Asian J Neurosurg. 2015 Oct-Dec;10(4):344-7. doi: 10.4103/1793-5482.162728.
9
Glioblastoma in a patient with neurofibromatosis type 1: a case report and review of the literature.1型神经纤维瘤病患者的胶质母细胞瘤：一例病例报告及文献综述
Brain Tumor Res Treat. 2014 Apr;2(1):36-8. doi: 10.14791/btrt.2014.2.1.36. Epub 2014 Apr 29.
10
Clinicopathologic study of glioblastoma in children with neurofibromatosis type 1.儿童神经纤维瘤病 1 型胶质母细胞瘤的临床病理研究。
Pediatr Blood Cancer. 2010 Jul 1;54(7):890-6. doi: 10.1002/pbc.22462.