一种新型黄素衍生物揭示了葡萄糖对脂肪细胞氧化应激的影响。
A novel flavin derivative reveals the impact of glucose on oxidative stress in adipocytes.
作者信息
Yeow Jonathan, Kaur Amandeep, Anscomb Matthew D, New Elizabeth J
机构信息
School of Chemistry, The University of Sydney, New South Wales 2006, Australia.
出版信息
Chem Commun (Camb). 2014 Aug 4;50(60):8181-4. doi: 10.1039/c4cc03464c.
PMID:24926565
Abstract
We present the synthesis and characterisation of naphthalimide-flavin redox sensor 1 (NpFR1), a novel flavin molecule that is almost non-fluorescent in reduced form, but oxidation gives rise to a 125-fold increase in fluorescence. Confocal microscopy experiments confirm that is sensitive to redox changes within living cells.
摘要
我们展示了萘二甲酰亚胺-黄素氧化还原传感器1（NpFR1）的合成与表征，这是一种新型黄素分子，其还原形式几乎无荧光，但氧化后荧光增强125倍。共聚焦显微镜实验证实其对活细胞内的氧化还原变化敏感。
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