Tigges M A, Casey L S, Koshland M E
Chiron Corporation, Emeryville, CA 94608.
Science. 1989 Feb 10;243(4892):781-6. doi: 10.1126/science.2492678.
The T cell lymphokine, interleukin-2 (IL-2), plays a pivotal role in an immune response by stimulating antigen-activated B lymphocytes to progress through the cell cycle and to differentiate into antibody-secreting cells. An IL-2 inducible B lymphoma line, in which the growth and differentiation responses are uncoupled, provides a model system for dissecting the signaling mechanisms operating in each response. This system was used to show that both signals are initiated by IL-2 binding to a single, unifunctional receptor complex. Moreover, both signals are transduced by a pathway that does not involve any known second messenger system and that can be blocked by a second T cell lymphokine, interleukin 4. These findings suggest that the pleiotrophic effects of IL-2 are determined by different translations of the signal in the nucleus.
T细胞淋巴因子白细胞介素-2（IL-2）通过刺激抗原激活的B淋巴细胞经历细胞周期并分化为抗体分泌细胞，在免疫反应中起关键作用。一种IL-2诱导的B淋巴瘤细胞系，其生长和分化反应是解偶联的，为剖析每种反应中运行的信号传导机制提供了一个模型系统。该系统用于表明这两种信号均由IL-2与单一的单功能受体复合物结合引发。此外，这两种信号均通过不涉及任何已知第二信使系统且可被第二种T细胞淋巴因子白细胞介素4阻断的途径进行转导。这些发现表明，IL-2的多效性作用是由细胞核中信号的不同转译所决定的。
