Solberg C, Hansen J B, Little C
Institute of Medical Biology, University of Tromsø, Norway.
Vox Sang. 1989;56(1):25-31. doi: 10.1111/j.1423-0410.1989.tb03042.x.
The stability of platelets stored in the second generation of container has been examined further. Platelet concentrates prepared in CPD anticoagulant were found to deteriorate fairly rapidly during storage if prepared from very freshly donated blood, whereas a more than 4-hour delay between donation and platelet isolation yielded platelet concentrates much more stable to storage. Delays of more than 2 h (relative to the time of donation) in the isolation of platelets led to decreases in the aggregation response to low or moderate doses of collagen. Platelets from blood collected into CPD adenine showed decreased aggregation responses relative to equivalent cells from blood collected into adenine-free anticoagulant. It seems that a decreased aggregation response is associated with improved storage properties.
第二代容器中储存的血小板的稳定性已得到进一步研究。如果从刚采集的血液中制备血小板浓缩物，发现用CPD抗凝剂制备的血小板浓缩物在储存期间会相当迅速地恶化，而献血与血小板分离之间延迟超过4小时所得到的血小板浓缩物在储存时则要稳定得多。血小板分离延迟超过2小时（相对于献血时间）会导致对低剂量或中等剂量胶原蛋白的聚集反应降低。与采集到不含腺嘌呤抗凝剂血液中的同等细胞相比，采集到CPD腺嘌呤血液中的血小板聚集反应降低。似乎聚集反应降低与储存性能改善有关。
