Futier Emmanuel, Jaber Samir
aDepartment of Anesthesiology and Critical Care Medicine, Estaing Hospital, University Teaching Hospital of Clermont-Ferrand bRetinoids, Reproduction and Developmental Diseases (R2D2) Unit, EA 7281, Clermont-Ferrand cDepartment of Anaesthesiology and Critical Care Medicine B (DAR B), Institut National de la Santé et de la Recherche Médicale (INSERM U-1046), Saint Eloi Teaching Hospital, University Hospital of Montpellier, Montpellier, France.
Curr Opin Crit Care. 2014 Aug;20(4):426-30. doi: 10.1097/MCC.0000000000000121.
To provide the most recent and relevant clinical evidence regarding the use of prophylactic lung-protective mechanical ventilation in abdominal surgery.
Evidence is accumulating, suggesting an association between intraoperative mechanical ventilation strategy and postoperative pulmonary complications in patients undergoing abdominal surgery. Nonprotective ventilator settings, especially high tidal volume (>10-12 ml/kg), very low level of positive end-expiratory pressure (PEEP, <5 cm H2O), or no PEEP, may cause alveolar overdistension and repetitive tidal recruitment leading to ventilator-associated lung injury in patients with healthy lungs. Stimulated by the previous findings in patients with acute respiratory distress syndrome, the use of lower tidal volume ventilation is becoming increasingly more common in the operating room. However, lowering tidal volume, though important, is only part of the overall multifaceted approach of lung-protective mechanical ventilation. Recent data provide compelling evidence that prophylactic lung-protective mechanical ventilation using lower tidal volume (6-8 ml/kg of predicted body weight), moderate PEEP (6-8 cm H2O), and recruitment maneuvers is associated with improved functional or physiological and clinical postoperative outcome in patients undergoing abdominal surgery.
The use of prophylactic lung-protective ventilation can help in improving the postoperative outcome.
提供关于腹部手术中预防性肺保护性机械通气应用的最新且相关的临床证据。
越来越多的证据表明,腹部手术患者的术中机械通气策略与术后肺部并发症之间存在关联。非保护性通气设置,尤其是高潮气量(>10 - 12 ml/kg)、极低水平的呼气末正压(PEEP,<5 cm H₂O)或无PEEP,可能会导致健康肺患者的肺泡过度扩张和反复潮气量再扩张,从而引发呼吸机相关性肺损伤。受急性呼吸窘迫综合征患者先前研究结果的启发,手术室中使用低潮气量通气越来越普遍。然而,降低潮气量虽然重要,但只是肺保护性机械通气整体多方面方法的一部分。近期数据提供了令人信服的证据,表明在腹部手术患者中,采用低潮气量(预测体重的6 - 8 ml/kg)、中度PEEP(6 - 8 cm H₂O)和肺复张手法进行预防性肺保护性机械通气与改善术后功能、生理及临床结局相关。
预防性肺保护性通气的应用有助于改善术后结局。