Zarek Judith, Koren Gideon
The Motherisk Program, Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, Hospital for Sick Children, Toronto ON.
J Obstet Gynaecol Can. 2014 Jun;36(6):506-509. doi: 10.1016/S1701-2163(15)30565-X.
Although an initial case series suggested that use of statins in pregnancy carried teratogenic risk, a recent meta-analysis of controlled observational studies has failed to corroborate this. A large number of potentially beneficial uses of statins in pregnant women have prompted a new evaluation of the risk-benefit ratio of these agents in pregnancy.
尽管最初的病例系列研究表明孕期使用他汀类药物存在致畸风险，但最近一项对对照观察性研究的荟萃分析并未证实这一点。他汀类药物在孕妇中大量潜在的有益用途促使人们对这些药物在孕期的风险效益比进行重新评估。
