白桑树根皮乙酸乙酯可溶部分对强迫游泳试验中大鼠不动行为的抗抑郁样作用。
Antidepressant-like effects of the ethyl acetate soluble fraction of the root bark of Morus alba on the immobility behavior of rats in the forced swim test.
机构信息
Food Resource Research Center, Korea Food Research Institute, Seongnam 463-746, Korea.
Research Group of Food Functionality, Korea Food Research Institute, Seongnam 463-746, Korea.
出版信息
Molecules. 2014 Jun 12;19(6):7981-9. doi: 10.3390/molecules19067981.
In this study, the antidepressant-like effects of Morus alba fractions in rats were investigated in the forced swim test (FST). Male Wistar rats (9-week-old) were administered orally the M. alba ethyl acetate (EtOAc 30 and 100 mg/kg) and M. alba n-butanol fractions (n-BuOH 30 and 100 mg/kg) every day for 7 consecutive days. On day 7, 1 h after the final administration of the fractions, the rats were exposed to the FST. M. alba EtOAc fraction at the dose of 100 mg/kg induced a decrease in immobility behavior (p < 0.01) with a concomitant increase in both climbing (p < 0.05) and swimming (p < 0.05) behaviors when compared with the control group, and M. alba EtOAc fraction at the dose of 100 mg/kg decreased the hypothalamic-pituitary-adrenal (HPA) axis response to the stress, as indicated by an attenuated corticosterone response and decreased c-fos immunoreactivity in the hippocampal and hypothalamic paraventricular nucleus (PVN) region. These findings demonstrated that M. alba EtOAc fraction have beneficial effects on depressive behaviors and restore both altered c-fos expression and HPA activity.
在这项研究中，我们研究了桑白皮提取物在大鼠强迫游泳试验（FST）中的抗抑郁样作用。雄性 Wistar 大鼠（9 周龄）每天口服给予桑白皮乙酸乙酯（EtOAc 30 和 100 mg/kg）和桑白皮正丁醇（n-BuOH 30 和 100 mg/kg），连续 7 天。第 7 天，在最后一次给药后 1 小时，将大鼠暴露于 FST 中。与对照组相比，桑白皮 EtOAc 提取物 100 mg/kg 剂量可减少不动行为（p<0.01），同时增加攀爬（p<0.05）和游泳（p<0.05）行为；桑白皮 EtOAc 提取物 100 mg/kg 剂量还可减轻下丘脑-垂体-肾上腺（HPA）轴对应激的反应，表现为皮质酮反应减弱和海马及下丘脑室旁核（PVN）区域 c-fos 免疫反应性降低。这些发现表明，桑白皮 EtOAc 提取物对抑郁行为有有益的作用，并恢复了改变的 c-fos 表达和 HPA 活性。
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