Lim Dong Wook, Baek Nam-In, Kim Yun Tai, Lee Changho, Kim In-Ho, Han Daeseok
Research Group of Innovative Special Food, Korea Food Research Institute, Seongnam, 463-746, Korea.
Graduate School of Biotechnology and Research Institute of Life Sciences and Resources, Kyung Hee University, Yongin, 446-701, Korea.
J Nat Med. 2016 Jul;70(3):679-82. doi: 10.1007/s11418-016-0975-3. Epub 2016 Feb 22.
In this study, we aimed to determine whether Sanggenon G, an active compound isolated from the root bark of Morus alba, exhibited enhanced anti-immobility activity with the addition of the α2-antagonist yohimbine in rats subjected to forced swim test (FST)-induced depression. Fluoxetine (a selective serotonin reuptake inhibitor) treatment in rats reduced the immobility time, and pretreatment with yohimbine significantly enhanced the antidepressant-like behavior of fluoxetine at 5, 10 and 20 mg/kg. Similarly, Sanggenon G significantly decreased the immobility time, reducing immobility by a maximum of 43.9 % when treated at a dose of 20 mg/kg. Furthermore, pretreatment with yohimbine significantly enhanced the antidepressant-like behavior of Sanggenon G at 5 and 10 mg/kg. Our findings suggest that the antidepressant-like effect of Sanggenon G could be facilitated by concomitant use of the α2-antagonist. Further studies are needed to evaluate the potential of Sanggenon G as an alternative therapeutic approach for the treatment of depression.
在本研究中，我们旨在确定从桑白皮中分离出的活性化合物桑根酮G，在接受强迫游泳试验（FST）诱导抑郁的大鼠中，与α2拮抗剂育亨宾联合使用时是否表现出增强的抗不动活性。大鼠接受氟西汀（一种选择性5-羟色胺再摄取抑制剂）治疗后不动时间减少，育亨宾在5、10和20mg/kg剂量下预处理可显著增强氟西汀的抗抑郁样行为。同样，桑根酮G显著减少了不动时间，在20mg/kg剂量治疗时，不动时间最多减少了43.9%。此外，育亨宾在5和10mg/kg剂量下预处理可显著增强桑根酮G的抗抑郁样行为。我们的研究结果表明，联合使用α2拮抗剂可促进桑根酮G的抗抑郁样作用。需要进一步研究来评估桑根酮G作为抑郁症替代治疗方法的潜力。
