Bailey J W, Heath H, Miles J M
Endocrine Research Unit, Mayo Clinic and Medical School, Rochester, MN 55905.
Am J Clin Nutr. 1989 Feb;49(2):385-8. doi: 10.1093/ajcn/49.2.385.
Previous studies suggested that acetate in parenteral solutions may adversely affect mineral metabolism by causing sequestration of inorganic phosphate and calcium in the liver. In this study, triacetin, a short-chain triglyceride of acetate and a potential parenteral nutrient, was infused for 3 h at an isocaloric rate in mongrel dogs (n = 6) to test its effects on serum phosphorus, calcium, and magnesium metabolism. There was no change in serum P or Ca. The serum Mg concentration decreased from 0.7 +/- 0.03 to 0.57 +/- 0.03 mmol/L (p less than 0.001) by 90 min and remained at this level for the remainder of the study. The triacetin infusion did not influence fractional urinary Mg excretion; thus, the decrease in serum Mg was likely because of an increase in cellular transport of this cation. A short-chain triglyceride administered to dogs at a rate approximating resting energy expenditure has no demonstrable adverse effects on mineral metabolism.
先前的研究表明，肠外营养液中的乙酸盐可能会通过使肝脏中的无机磷酸盐和钙螯合而对矿物质代谢产生不利影响。在本研究中，以等热量速率向杂种犬（n = 6）输注三醋精（一种乙酸盐的短链甘油三酯，也是一种潜在的肠外营养物质）3小时，以测试其对血清磷、钙和镁代谢的影响。血清磷或钙没有变化。血清镁浓度在90分钟时从0.7±0.03降至0.57±0.03 mmol/L（p<0.001），并在研究的剩余时间内保持在该水平。三醋精输注不影响尿镁排泄分数；因此，血清镁的降低可能是由于这种阳离子的细胞转运增加所致。以接近静息能量消耗的速率给犬类施用短链甘油三酯对矿物质代谢没有明显的不利影响。
