Bleiberg B, Beers T R, Persson M, Miles J M
Endocrine Research Unit, Mayo Medical School, Rochester, MN.
Am J Clin Nutr. 1993 Dec;58(6):908-11. doi: 10.1093/ajcn/58.6.908.
Triacetin is a water-soluble triglyceride that may have a role as a parenteral nutrient. In the present study triacetin was administered intravenously to mongrel dogs (n = 10) 2 wk after surgical placement of blood-sampling catheters in the aorta and in the portal, hepatic, renal, and femoral veins. [1-14C]Acetate was infused to allow quantification of organ uptake of acetate as well as systemic turnover and oxidation. Systemic acetate turnover accounted for approximately 70% of triacetin-derived acetate, assuming complete hydrolysis of the triglyceride. Approximately 80% of systemic acetate uptake was rapidly oxidized. Significant acetate uptake was demonstrated in all tissues (liver, 559 +/- 68; intestine, 342 +/- 23; hindlimb, 89 +/- 7; and kidney, 330 +/- 37 mumol/min). In conclusion, during intravenous administration in dogs, the majority of infused triacetin undergoes intravascular hydrolysis, and the majority of the resulting acetate is oxidized. Thus, energy in the form of short-chain fatty acids can be delivered to a resting gut via intravenous infusion of a short-chain triglyceride.
甘油三乙酸酯是一种水溶性甘油三酯，可能作为肠外营养物质发挥作用。在本研究中，在杂种犬（n = 10）的主动脉以及门静脉、肝静脉、肾静脉和股静脉中手术植入采血导管2周后，静脉注射甘油三乙酸酯。注入[1-¹⁴C]乙酸盐以定量乙酸盐的器官摄取以及全身周转和氧化。假设甘油三酯完全水解，全身乙酸盐周转约占甘油三乙酸酯衍生乙酸盐的70%。全身摄取的乙酸盐约80%被迅速氧化。所有组织（肝脏，559±68；肠道，342±23；后肢，89±7；肾脏，330±37 μmol/min）均显示有显著的乙酸盐摄取。总之，在犬静脉给药期间，大部分注入的甘油三乙酸酯发生血管内水解，生成的乙酸盐大部分被氧化。因此，短链脂肪酸形式的能量可以通过静脉输注短链甘油三酯传递到静息的肠道。
