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ESHRE伦理与法律特别工作组22:胚胎植入前遗传学诊断

ESHRE task force on ethics and Law22: preimplantation genetic diagnosis.

作者信息

De Wert G, Dondorp W, Shenfield F, Devroey P, Tarlatzis B, Barri P, Diedrich K, Provoost V, Pennings G

机构信息

Department of Health, Ethics & Society, Research Institutes CAPHRI and GROW, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands

Department of Health, Ethics & Society, Research Institutes CAPHRI and GROW, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands.

出版信息

Hum Reprod. 2014 Aug;29(8):1610-7. doi: 10.1093/humrep/deu132. Epub 2014 Jun 13.

Abstract

This Task Force document discusses some relatively unexplored ethical issues involved in preimplantation genetic diagnosis (PGD). The document starts from the wide consensus that PGD is ethically acceptable if aimed at helping at-risk couples to avoid having a child with a serious disorder. However, if understood as a limit to acceptable indications for PGD, this 'medical model' may turn out too restrictive. The document discusses a range of possible requests for PGD that for different reasons fall outwith the accepted model and argues that instead of rejecting those requests out of hand, they need to be independently assessed in the light of ethical criteria. Whereas, for instance, there is no good reason for rejecting PGD in order to avoid health problems in a third generation (where the second generation would be healthy but faced with burdensome reproductive choices if wanting to have children), using PGD to make sure that one's child will have the same disorder or handicap as its parents, is ethically unacceptable.

摘要

本特别工作组文件讨论了植入前基因诊断(PGD)中一些相对未被探索的伦理问题。该文件始于一个广泛的共识,即如果PGD旨在帮助有风险的夫妇避免生育患有严重疾病的孩子,那么在伦理上是可以接受的。然而,如果将其理解为对PGD可接受适应症的一种限制,这种“医学模式”可能会显得过于严格。该文件讨论了一系列因不同原因超出公认模式的PGD可能请求,并认为不应立即拒绝这些请求,而需要根据伦理标准进行独立评估。例如,没有充分理由拒绝PGD以避免第三代出现健康问题(第二代将是健康的,但如果想要孩子会面临繁重的生育选择),而使用PGD来确保自己的孩子患有与父母相同的疾病或残疾,在伦理上是不可接受的。

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