Enomoto Laura M, Hollenbeak Christopher S, Bhayani Neil H, Dillon Peter W, Gusani Niraj J
Department of Surgery, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA,
J Gastrointest Surg. 2014 Aug;18(8):1416-22. doi: 10.1007/s11605-014-2569-2. Epub 2014 Jun 14.
This study compared postoperative complications of patients who underwent pancreaticoduodenectomy (PD) recorded in the National Surgical Quality Improvement Program (NSQIP) to patients who underwent PD recorded in the Healthcare Cost and Utilization Project (HCUP) National Inpatient Sample (NIS).
Data included 8,822 PD cases recorded in NSQIP and 9,827 PD cases recorded in NIS performed between 2005 and 2010. Eighteen postoperative adverse outcomes were identified in NSQIP and then matched to corresponding International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) codes in NIS. Using logistic regression, the relationship between database and postoperative complications was determined while accounting for patient factors.
Patients undergoing PD in the NIS were more likely to have several adverse outcomes, including urinary tract infection (odds ratio (OR) = 1.42, p < 0.001), pneumonia (OR = 1.51, p < 0.001), renal insufficiency (OR = 2.39, p < 0.001), renal failure (OR = 1.67, p = 0.005), graft/prosthetic failure (OR = 9.35, p < 0.001), and longer length of stay (1.1 days, p < 0.001). They were less likely to have cardiac arrest (OR = 0.45, p = 0.002), postoperative sepsis (OR = 0.38, p < 0.001), deep vein thrombosis (OR = 0.18, p < 0.001), and cerebrovascular accident (OR = 0.04, p = 0.003).
There is considerable discordance between NSQIP and NIS in the assessment of postoperative complications following PD, which underscores the value of recognizing the capabilities and limitations of each data source.
本研究比较了在国家外科质量改进计划(NSQIP)中记录的接受胰十二指肠切除术(PD)的患者与在医疗成本和利用项目(HCUP)国家住院样本(NIS)中记录的接受PD的患者的术后并发症。
数据包括2005年至2010年间在NSQIP中记录的8822例PD病例和在NIS中记录的9827例PD病例。在NSQIP中确定了18种术后不良结局,然后将其与NIS中相应的国际疾病分类第九版临床修订本(ICD-9-CM)编码进行匹配。使用逻辑回归,在考虑患者因素的同时确定数据库与术后并发症之间的关系。
在NIS中接受PD的患者更有可能出现几种不良结局,包括尿路感染(比值比(OR)=1.42,p<0.001)、肺炎(OR=1.51,p<0.001)、肾功能不全(OR=2.39,p<0.001)、肾衰竭(OR=1.67,p=0.005)、移植物/假体功能衰竭(OR=9.35,p<0.001)以及住院时间更长(1.1天,p<0.001)。他们发生心脏骤停(OR=0.45,p=0.002)、术后败血症(OR=0.38,p<0.001)、深静脉血栓形成(OR=0.18,p<0.001)和脑血管意外(OR=0.04,p=0.003)的可能性较小。
NSQIP和NIS在PD术后并发症评估方面存在相当大的不一致,这凸显了认识每个数据源的能力和局限性的价值。