Department of Dermatology, Qianfoshan Hospital, Shandong University, 16766# Jing-Shi Road, Jinan 250014, China.
BMC Infect Dis. 2014 Jun 13;14:329. doi: 10.1186/1471-2334-14-329.
Condylomata acuminata (genital warts) is the most common sexually transmitted disease, and imiquimod is the sole FDA-approved medication for combating this condition. Vitiligo associated with imiquimod treatment of condylomata acuminata is rare.
A 28-year-old male with condylomata acuminata of the penis presented to our clinic. After removing his condylomata acuminata, we advised him to use imiquimod 5% cream to prevent relapse. When he presented to our clinic again about 12 weeks later, he complained of vitiligo patches on his penis and scrotum. Physical examination showed vitiligo patches involving the glans penis, shaft of the penis, and scrotum, and remaining pigmented areas within the plaques of vitiligo.A skin biopsy of the dorsal surface of the penis showed a complete absence of melanocytes and melanin granules in the basal layer; the dermis was normal.
This is the first report of a case of imiquimod-induced vitiligo diagnosed by histopathological examination. This adverse effect should be considered when dermatologists prescribe this medication.
尖锐湿疣（生殖器疣）是最常见的性传播疾病，咪喹莫特是唯一被 FDA 批准用于治疗该疾病的药物。与咪喹莫特治疗尖锐湿疣相关的白癜风较为罕见。
一名 28 岁男性因阴茎尖锐湿疣就诊于我院。在切除尖锐湿疣后，我们建议他使用 5%咪喹莫特乳膏预防复发。大约 12 周后，他再次因阴茎和阴囊上出现白癜风斑块而就诊。体格检查显示阴茎头部、阴茎干和阴囊上有白癜风斑块，斑块内有色素沉着区。阴茎背部皮肤活检显示基底层完全缺乏黑素细胞和黑素颗粒；真皮正常。
这是首例经组织病理学检查诊断的咪喹莫特诱导性白癜风病例。皮肤科医生开具此药时应考虑这种不良反应。
