León-Rivera Ismael, Villeda-Hernández Juana, Campos-Peña Victoria, Aguirre-Moreno Alma, Estrada-Soto Samuel, Navarrete-Vázquez Gabriel, Rios María Yolanda, Aguilar-Guadarrama Berenice, Castillo-España Patricia, Rivera-Leyva Julio César
Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001 Col. Chamilpa 62209, Cuernavaca, Morelos, Mexico.
Laboratorio Experimental de Neuropatología, Instituto Nacional de Neurología y Neurocirugía, MVS, SSA. Insurgentes Sur 3877, Col. La Fama 14269 Distrito Federal, Mexico.
Bioorg Med Chem Lett. 2014 Aug 1;24(15):3541-5. doi: 10.1016/j.bmcl.2014.05.055. Epub 2014 May 27.
Stansin 6 a tetrasaccharide resin glycoside isolated from the root of Ipomoea stans was evaluated as anticonvulsant and neuroprotective in kainic acid-induced seizures of rats. Intraperitoneal injection of kainic acid (10 mg/kg) induced typical behavioral seizures such as wet dog shakes and limbic seizures, and histopathological changes in the hippocampus (degeneration and loss of pyramidal cells in CA1 to CA4 areas). Stansin 6 (10-80 mg/kg) had no effect on the behavior of rats and did not induce hippocampal damage. Pretreatment with stansin 6 inhibited convulsions in rats from kainic acid-induced seizures, reduced the degeneration pattern in the CA3 region, decreased astrocytic reactivity, and reduced the expression of IL-1β and TNF-α induced by kainic acid. These results suggest that stansin 6 possesses neuroprotective and anticonvulsant activities.
从甘薯（Ipomoea stans）根部分离得到的四糖树脂糖苷斯坦辛6（Stansin 6），在海藻酸诱导的大鼠癫痫发作中进行了抗惊厥和神经保护作用的评估。腹腔注射海藻酸（10毫克/千克）会诱发典型的行为性癫痫发作，如湿狗样抖动和边缘叶癫痫发作，以及海马体的组织病理学变化（CA1至CA4区锥体细胞的变性和丧失）。斯坦辛6（10 - 80毫克/千克）对大鼠行为没有影响，也不会诱发海马体损伤。用斯坦辛6预处理可抑制大鼠由海藻酸诱导的癫痫发作，减少CA3区的变性模式，降低星形细胞反应性，并减少海藻酸诱导的IL - 1β和TNF - α的表达。这些结果表明，斯坦辛6具有神经保护和抗惊厥活性。
