Herrera-Ruiz Maribel, Gutiérrez Carmen, Enrique Jiménez-Ferrer J, Tortoriello Jaime, Mirón Gumersindo, León Ismael
Centro de Investigación Biomédica del Sur, IMSS, Argentina 1, Col. Centro 62790 Xochitepec, Morelos, México.
J Ethnopharmacol. 2007 Jun 13;112(2):243-7. doi: 10.1016/j.jep.2007.03.004. Epub 2007 Mar 7.
Ipomoea stans Cav., popularly known as "tumbavaqueros", is a plant widely used in Mexico for the treatment of epileptic seizures and nervous disorders. This work researched the action of the ethyl acetate extract from the root of I. stans (IS-EAE) on the central nervous system (CNS). The administration of IS-EAE (2.5 and 5.0 mg/kg, i.p.) produced an anxiolytic effect in mice. This extract (20.0 and 40.0 mg/kg, i.p.) significantly reduced spontaneous motor activity. 2.5, 5.0, 10.0, and 20.0 mg/kg of IS-EAE protected mice against pentylenetetrazole-induced convulsions and increased the hypnotic effect induced by pentobarbital. The administration of IS-EAE was able to increase the release of GABA in brain cortex of mice. These results suggest that IS-EAE possess anxiolytic and anticonvulsant effects, and could have potential sedative effect, probably through a GABAergic system. The extract did not show antidepressant effects on mice exposed to forced swimming test.
圆叶茑萝，俗称“tumbavaqueros”，是一种在墨西哥广泛用于治疗癫痫发作和神经紊乱的植物。这项研究考察了圆叶茑萝根的乙酸乙酯提取物（IS-EAE）对中枢神经系统（CNS）的作用。腹腔注射IS-EAE（2.5和5.0毫克/千克）对小鼠产生抗焦虑作用。该提取物（腹腔注射20.0和40.0毫克/千克）显著降低自发运动活性。2.5、5.0、10.0和20.0毫克/千克的IS-EAE可保护小鼠免受戊四氮诱导的惊厥，并增强戊巴比妥诱导的催眠作用。给予IS-EAE能够增加小鼠大脑皮层中γ-氨基丁酸（GABA）的释放。这些结果表明，IS-EAE具有抗焦虑和抗惊厥作用，可能通过GABA能系统具有潜在的镇静作用。该提取物对强迫游泳试验中的小鼠没有显示出抗抑郁作用。
