人肝脏线粒体对硫化氢的氧化作用。
Oxidation of hydrogen sulfide by human liver mitochondria.
作者信息
Helmy Nada, Prip-Buus Carina, Vons Corinne, Lenoir Véronique, Abou-Hamdan Abbas, Guedouari-Bounihi Hala, Lombès Anne, Bouillaud Frédéric
机构信息
Inserm U1016, Institut Cochin, 75014 Paris, France; CNRS UMR8104, Institut Cochin, 75014 Paris, France; Université Paris Descartes UMR-S1016, Institut Cochin, 75014 Paris, France; Service de chirurgie digestive et métabolique, APHP, Hôpitaux universitaires de Seine Saint Denis Hôpital Jean Verdier, 93143 Bondy Cedex, France; Université Paris 13, Bobigny, France.
Inserm U1016, Institut Cochin, 75014 Paris, France; CNRS UMR8104, Institut Cochin, 75014 Paris, France; Université Paris Descartes UMR-S1016, Institut Cochin, 75014 Paris, France.
出版信息
Nitric Oxide. 2014 Sep 15;41:105-12. doi: 10.1016/j.niox.2014.05.011. Epub 2014 Jun 11.
Hydrogen sulfide (H2S) is the third gasotransmitter discovered. Sulfide shares with the two others (NO and CO) the same inhibiting properties towards mitochondrial respiration. However, in contrast with NO or CO, sulfide at concentrations lower than the toxic (μM) level is an hydrogen donor and a substrate for mitochondrial respiration. This is due to the activity of a sulfide quinone reductase found in a large majority of mitochondria. An ongoing study of the metabolic state of liver in obese patients allowed us to evaluate the sulfide oxidation capacity with twelve preparations of human liver mitochondria. The results indicate relatively high rates of sulfide oxidation with a large variability between individuals. These observations made with isolated mitochondria appear in agreement with the main characteristics of sulfide oxidation as established before with the help of cellular models.
硫化氢（H₂S）是发现的第三种气体信号分子。硫化物与其他两种（一氧化氮和一氧化碳）对线粒体呼吸具有相同的抑制特性。然而，与一氧化氮或一氧化碳不同的是，浓度低于有毒（微摩尔）水平的硫化物是一种氢供体和线粒体呼吸的底物。这是由于在绝大多数线粒体中发现的一种硫化物醌还原酶的活性。一项正在进行的对肥胖患者肝脏代谢状态的研究使我们能够用12份人肝脏线粒体标本评估硫化物氧化能力。结果表明硫化物氧化速率相对较高，个体之间存在很大差异。这些在分离的线粒体上的观察结果似乎与之前借助细胞模型确定的硫化物氧化的主要特征一致。
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