一项针对多发性硬化症患者记忆再训练6个月后大脑功能活动的试点研究：MEMREHAB试验。
A pilot study examining functional brain activity 6 months after memory retraining in MS: the MEMREHAB trial.
作者信息
Dobryakova Ekaterina, Wylie Glenn R, DeLuca John, Chiaravalloti Nancy D
机构信息
Kessler Foundation Research Center, 300 Executive Drive, Suite 70, West Orange, NJ, 07052, USA.
出版信息
Brain Imaging Behav. 2014 Sep;8(3):403-6. doi: 10.1007/s11682-014-9309-9.
Abstract
Cognitive impairment in individuals with multiple sclerosis (MS) is now well recognized. One of the most common cognitive deficits is found in memory functioning, largely due to impaired acquisition. We examined functional brain activity 6 months after memory retraining in individuals with MS. The current report presents long term follow-up results from a randomized clinical trial on a memory rehabilitation protocol known as the modified Story Memory Technique. Behavioral memory performance and brain activity of all participants were evaluated at baseline, immediately after treatment, and 6 months after treatment. Results revealed that previously observed increases in patterns of cerebral activation during learning immediately after memory training were maintained 6 months post training.
摘要
多发性硬化症（MS）患者的认知障碍现已得到充分认识。最常见的认知缺陷之一存在于记忆功能方面，这主要是由于记忆获取受损所致。我们对MS患者进行记忆再训练6个月后检查了其大脑功能活动。本报告呈现了一项关于一种名为改良故事记忆技术的记忆康复方案的随机临床试验的长期随访结果。在基线、治疗后即刻以及治疗后6个月对所有参与者的行为记忆表现和大脑活动进行了评估。结果显示，在记忆训练后即刻学习期间观察到的大脑激活模式增加在训练后6个月得以维持。
相似文献
1
A pilot study examining functional brain activity 6 months after memory retraining in MS: the MEMREHAB trial.一项针对多发性硬化症患者记忆再训练6个月后大脑功能活动的试点研究：MEMREHAB试验。
Brain Imaging Behav. 2014 Sep;8(3):403-6. doi: 10.1007/s11682-014-9309-9.
2
A pilot study of changes in functional brain activity during a working memory task after mSMT treatment: The MEMREHAB trial.一项关于 mSMT 治疗后工作记忆任务中大脑功能活动变化的初步研究：MEMREHAB 试验。
Mult Scler Relat Disord. 2016 May;7:76-82. doi: 10.1016/j.msard.2016.03.012. Epub 2016 Mar 24.
3
Efficacy of the Spanish modified Story Memory Technique in Mexicans with multiple sclerosis: A pilot randomized controlled trial.西班牙改良故事记忆技术对多发性硬化症墨西哥患者的疗效：一项初步随机对照试验。
NeuroRehabilitation. 2019;45(3):349-358. doi: 10.3233/NRE-192808.
4
Functional connectivity changes within specific networks parallel the clinical evolution of multiple sclerosis.特定网络内的功能连接变化与多发性硬化症的临床进展平行。
Mult Scler. 2014 Jul;20(8):1050-7. doi: 10.1177/1352458513515082. Epub 2013 Dec 10.
5
Differential cerebellar activation on functional magnetic resonance imaging during working memory performance in persons with multiple sclerosis.多发性硬化症患者在工作记忆表现期间功能磁共振成像上的小脑激活差异。
Arch Phys Med Rehabil. 2004 Apr;85(4):635-9. doi: 10.1016/j.apmr.2003.07.016.
6
Multiple brain networks support processing speed abilities of patients with multiple sclerosis.多发性硬化症患者的处理速度能力由多个脑网络支持。
Postgrad Med. 2019 Sep;131(7):523-532. doi: 10.1080/00325481.2019.1663706. Epub 2019 Sep 16.
7
Mapping face encoding using functional MRI in multiple sclerosis across disease phenotypes.多模态功能磁共振成像在多发性硬化症不同疾病表型中的面孔编码研究
Brain Imaging Behav. 2017 Oct;11(5):1238-1247. doi: 10.1007/s11682-016-9591-9.
8
Using mental visual imagery to improve autobiographical memory and episodic future thinking in relapsing-remitting multiple sclerosis patients: A randomised-controlled trial study.运用心理视觉意象改善复发缓解型多发性硬化症患者的自传体记忆和情景未来思维：一项随机对照试验研究。
Restor Neurol Neurosci. 2015;33(5):621-38. doi: 10.3233/RNN-140461.
9
Feasibility and effects of a group kickboxing program for individuals with multiple sclerosis: a pilot report.针对多发性硬化症患者的团体踢拳项目的可行性及效果：一项初步报告
J Bodyw Mov Ther. 2012 Jan;16(1):7-13. doi: 10.1016/j.jbmt.2010.09.002. Epub 2010 Sep 29.
10
fMRI evidence of brain reorganization during attention and memory tasks in multiple sclerosis.多发性硬化症患者在注意力和记忆任务期间大脑重组的功能磁共振成像证据。
Neuroimage. 2004 Mar;21(3):858-67. doi: 10.1016/j.neuroimage.2003.10.004.
引用本文的文献
1
Functional MRI and cognition in multiple sclerosis-Where are we now?多发性硬化症中的功能磁共振成像与认知——我们目前的进展如何？
J Neuroimaging. 2025 Jan-Feb;35(1):e13252. doi: 10.1111/jon.13252.
2
Advanced neuroimaging techniques to explore the effects of motor and cognitive rehabilitation in multiple sclerosis.采用先进的神经影像学技术探索运动和认知康复对多发性硬化症的影响。
J Neurol. 2024 Jul;271(7):3806-3848. doi: 10.1007/s00415-024-12395-0. Epub 2024 May 1.
3
Kessler Foundation Strategy-Based Training to Enhance Memory (KF-STEM™): Study protocol for a single site double-blind randomized, clinical trial in Multiple Sclerosis.凯斯勒基金会基于策略的记忆增强训练（KF-STEM™）：一项针对多发性硬化症的单中心双盲随机临床试验的研究方案。
Contemp Clin Trials Commun. 2022 Nov 3;30:101026. doi: 10.1016/j.conctc.2022.101026. eCollection 2022 Dec.
4
Memory rehabilitation for people with multiple sclerosis.多发性硬化症患者的记忆康复。
Cochrane Database Syst Rev. 2021 Oct 18;10(10):CD008754. doi: 10.1002/14651858.CD008754.pub4.
5
Focus on neglected features of cognitive rehabilitation in MS: Setting and mode of the treatment.关注 MS 认知康复中被忽视的特征：治疗的设置和模式。
Mult Scler. 2022 Jun;28(7):1009-1019. doi: 10.1177/1352458520966300. Epub 2020 Oct 13.
6
Cognitive impairment in multiple sclerosis: clinical management, MRI, and therapeutic avenues.多发性硬化症的认知障碍：临床管理、MRI 和治疗途径。
Lancet Neurol. 2020 Oct;19(10):860-871. doi: 10.1016/S1474-4422(20)30277-5. Epub 2020 Sep 16.
7
Study protocol: improving cognition in people with progressive multiple sclerosis: a multi-arm, randomized, blinded, sham-controlled trial of cognitive rehabilitation and aerobic exercise (COGEx).研究方案：改善进行性多发性硬化症患者的认知：一项关于认知康复和有氧运动的多组、随机、双盲、假对照试验（COGEx）
BMC Neurol. 2020 May 22;20(1):204. doi: 10.1186/s12883-020-01772-7.
8
Treatment and management of cognitive dysfunction in patients with multiple sclerosis.多发性硬化症患者认知功能障碍的治疗与管理
Nat Rev Neurol. 2020 Jun;16(6):319-332. doi: 10.1038/s41582-020-0355-1. Epub 2020 May 5.
9
Systematic, Evidence-Based Review of Exercise, Physical Activity, and Physical Fitness Effects on Cognition in Persons with Multiple Sclerosis.对运动、身体活动和身体素质对多发性硬化症患者认知影响的系统循证综述
Neuropsychol Rev. 2016 Sep;26(3):271-294. doi: 10.1007/s11065-016-9324-2. Epub 2016 Jul 22.
10
A pilot study of changes in functional brain activity during a working memory task after mSMT treatment: The MEMREHAB trial.一项关于 mSMT 治疗后工作记忆任务中大脑功能活动变化的初步研究：MEMREHAB 试验。
Mult Scler Relat Disord. 2016 May;7:76-82. doi: 10.1016/j.msard.2016.03.012. Epub 2016 Mar 24.
本文引用的文献
1
An RCT to treat learning impairment in multiple sclerosis: The MEMREHAB trial.一项治疗多发性硬化学习障碍的 RCT：MEMREHAB 试验。
Neurology. 2013 Dec 10;81(24):2066-72. doi: 10.1212/01.wnl.0000437295.97946.a8. Epub 2013 Nov 8.
2
Changes of brain resting state functional connectivity predict the persistence of cognitive rehabilitation effects in patients with multiple sclerosis.脑静息态功能连接的变化可预测多发性硬化症患者认知康复效果的持续性。
Mult Scler. 2014 May;20(6):686-94. doi: 10.1177/1352458513505692. Epub 2013 Sep 26.
3
Neuropsychological rehabilitation has beneficial effects on perceived cognitive deficits in multiple sclerosis during nine-month follow-up.神经心理学康复在九个月的随访中对多发性硬化症患者认知缺陷的感知有有益影响。
J Neurol Sci. 2013 Nov 15;334(1-2):154-60. doi: 10.1016/j.jns.2013.08.017. Epub 2013 Aug 17.
4
Computer-assisted cognitive rehabilitation of attention deficits for multiple sclerosis: a randomized trial with fMRI correlates.计算机辅助认知康复治疗多发性硬化症注意力缺陷：一项具有 fMRI 相关性的随机试验。
Neurorehabil Neural Repair. 2013 May;27(4):284-95. doi: 10.1177/1545968312465194. Epub 2012 Nov 27.
5
Induced brain plasticity after a facilitation programme for autobiographical memory in multiple sclerosis: a preliminary study.多发性硬化症患者自传体记忆促进训练后的脑可塑性诱导：一项初步研究。
Mult Scler Int. 2012;2012:820240. doi: 10.1155/2012/820240. Epub 2012 Oct 18.
6
Increased cerebral activation after behavioral treatment for memory deficits in MS.多发性硬化症记忆缺陷的行为治疗后大脑激活增加。
J Neurol. 2012 Jul;259(7):1337-46. doi: 10.1007/s00415-011-6353-x. Epub 2012 Jan 12.
7
Neural activity that predicts subsequent memory and forgetting: a meta-analysis of 74 fMRI studies.预测后续记忆和遗忘的神经活动：74 项 fMRI 研究的荟萃分析。
Neuroimage. 2011 Feb 1;54(3):2446-61. doi: 10.1016/j.neuroimage.2010.09.045. Epub 2010 Sep 30.
8
The Open-Trial Selective Reminding Test (OT-SRT) as a tool for the assessment of learning and memory.开放试验选择性提醒测试（OT-SRT）作为一种评估学习与记忆的工具。
Clin Neuropsychol. 2009 Feb;23(2):231-54. doi: 10.1080/13854040802121158.
9
Brain areas underlying visual mental imagery and visual perception: an fMRI study.视觉心理意象和视觉感知的脑区基础：一项功能磁共振成像研究。
Brain Res Cogn Brain Res. 2004 Jul;20(2):226-41. doi: 10.1016/j.cogbrainres.2004.02.012.
10
Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis.多发性硬化症推荐诊断标准：国际多发性硬化症诊断小组指南
Ann Neurol. 2001 Jul;50(1):121-7. doi: 10.1002/ana.1032.
Zotero 插件