Vidal Adriana C, Smith Jennifer S, Valea Fidel, Bentley Rex, Gradison Maggie, Yarnall Kimberly S H, Ford Anne, Overcash Francine, Grant Kathy, Murphy Susan K, Hoyo Cathrine
Program of Cancer Detection, Prevention and Control, Division of Clinical and Epidemiologic Research, Department of Obstetrics and Gynecology, Duke University School of Medicine, P.O. Box 104006, Durham, NC, 27710, USA,
Cancer Causes Control. 2014 Aug;25(8):1055-62. doi: 10.1007/s10552-014-0406-2. Epub 2014 Jun 14.
For poorly understood reasons, invasive cervical cancer (ICC) incidence and mortality rates are higher in women of African descent. Oncogenic human papillomavirus (HPV) genotypes distribution may vary between European American (EA) and African-American (AA) women and may contribute to differences in ICC incidence. The current study aimed at disentangling differences in HPV distribution among AA and EA women.
Five-hundred and seventy-two women were enrolled at the time of colposcopic evaluation following an abnormal liquid-based cytology screen. HPV infections were detected using HPV linear array, and chi-squared tests and linear regression models were used to compare HPV genotypes across racial/ethnic groups by CIN status.
Of the 572 participants, 494 (86 %) had detectable HPV; 245 (43 %) had no CIN lesion, 239 (42 %) had CIN1, and 88 (15 %) had CIN2/3. Seventy-three percent of all women were infected with multiple HPV genotypes. After adjusting for race, age, parity, income, oral contraception use, and current smoking, AAs were two times less likely to harbor HPV 16/18 (OR 0.48, 95 % CI 0.21-0.94, p = 0.03) when all women were considered. This association remained unchanged when only women with CIN2/3 lesions were examined (OR 0.22, 95 % CI 0.05-0.95, p = 0.04). The most frequent high-risk HPV genotypes detected among EAs were 16, 18, 56, 39, and 66, while HPV genotypes 33, 35, 45, 58, and 68 were the most frequent ones detected in AAs.
Our data suggest that while HPV 16/18 are the most common genotypes among EA women with CIN, AAs may harbor different genotypes.
由于一些尚不清楚的原因，非洲裔女性的浸润性宫颈癌（ICC）发病率和死亡率较高。致癌性人乳头瘤病毒（HPV）基因型分布在欧美裔（EA）和非裔美国（AA）女性中可能存在差异，这可能导致ICC发病率的差异。本研究旨在厘清AA和EA女性之间HPV分布的差异。
在液基细胞学筛查异常后进行阴道镜评估时，招募了572名女性。使用HPV线性阵列检测HPV感染，并通过卡方检验和线性回归模型按CIN状态比较不同种族/族裔群体的HPV基因型。
在572名参与者中，494名（86%）检测到HPV；245名（43%）无CIN病变，239名（42%）有CIN1，88名（15%）有CIN2/3。所有女性中有73%感染了多种HPV基因型。在对种族、年龄、产次、收入、口服避孕药使用情况和当前吸烟情况进行调整后，当考虑所有女性时，AA女性携带HPV 16/18的可能性降低两倍（OR 0.48，95%CI 0.21 - 0.94，p = 0.03）。仅检查有CIN2/3病变的女性时，这种关联保持不变（OR 0.22，95%CI 0.05 - 0.95，p = 0.04）。在EA女性中检测到的最常见高危HPV基因型为16、18、56、39和66，而在AA女性中检测到的最常见HPV基因型为33、35、45、58和68。
我们的数据表明，虽然HPV 16/18是EA女性CIN中最常见的基因型，但AA女性可能携带不同的基因型。
