Wadhwani Nisha, Patil Vidya, Pisal Hemlata, Joshi Asmita, Mehendale Savita, Gupte Sanjay, Wagh Girija, Joshi Sadhana
Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune Satara Road, Pune 411043, India.
Department of Obstetrics and Gynecology, Bharati Medical College and Hospital, Bharati Vidyapeeth University, Pune 411043, India.
Prostaglandins Leukot Essent Fatty Acids. 2014 Jul-Aug;91(1-2):21-30. doi: 10.1016/j.plefa.2014.05.006. Epub 2014 May 28.
Our previous cross-sectional studies have shown altered proportions of long chain polyunsaturated fatty acids (LCPUFA) in preeclampsia (PE) at the end of pregnancy when the pathology has already progressed. The present longitudinal study for the first time reports fatty acid proportions from 16th week of gestation till delivery and placental transport in PE. This is a hospital based study where women were recruited in early pregnancy. Maternal blood was collected at 3 time points i.e. T1=16-20th week, T2=26-30th week and T3=at delivery. Cord blood and placenta were collected at delivery. This study reports data on 140 normotensive control (NC) and 54 PE women. In PE we report lower proportions of DHA in maternal plasma at T1, cord plasma and placenta (p<0.05 for all). The mRNA levels of placental ∆5 desaturase, fatty acid transport proteins -1, -4, were lower (p<0.05 for all) in PE. There was also a positive association between cord and maternal plasma DHA and total omega-3 fatty acids at T1. This study demonstrates that women with PE have lower fatty acids stores at 16-20th week of gestation and lower placental synthesis and transport. It is likely that supplementation of omega-3 fatty acids during the 16-20th week of gestation may help in improving fatty acid status in infants born to mothers with PE.
我们之前的横断面研究表明，在妊娠末期子痫前期（PE）病情已经进展时，长链多不饱和脂肪酸（LCPUFA）的比例发生了改变。本纵向研究首次报告了PE患者从妊娠第16周直至分娩时的脂肪酸比例以及胎盘转运情况。这是一项基于医院的研究，在妊娠早期招募女性。在3个时间点采集母体血液，即T1 = 妊娠16 - 20周、T2 = 妊娠26 - 30周和T3 = 分娩时。在分娩时采集脐带血和胎盘。本研究报告了140名血压正常对照者（NC）和54名PE患者的数据。在PE患者中，我们报告在T1时母体血浆、脐带血浆和胎盘内DHA的比例较低（所有p值均<0.05）。PE患者胎盘∆5去饱和酶、脂肪酸转运蛋白-1、-4的mRNA水平较低（所有p值均<0.05）。在T1时，脐带血和母体血浆中的DHA与总ω-3脂肪酸之间也存在正相关。本研究表明，患有PE的女性在妊娠16 - 20周时脂肪酸储备较低，胎盘合成和转运能力也较低。在妊娠16 - 20周期间补充ω-3脂肪酸可能有助于改善PE母亲所生婴儿的脂肪酸状况。
