子痫前期患者胎盘二十二碳六烯酸水平降低与可溶性血管内皮生长因子受体 1 水平升高有关。

Reduced placental docosahexaenoic acid levels associated with increased levels of sFlt-1 in preeclampsia.

机构信息

Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune 411043, India.

出版信息

Prostaglandins Leukot Essent Fatty Acids. 2011 Jan-Feb;84(1-2):51-5. doi: 10.1016/j.plefa.2010.09.005. Epub 2010 Oct 16.

DOI:10.1016/j.plefa.2010.09.005

PMID:20956072

Abstract

Our earlier studies, in preeclamptic women have shown altered levels of long chain polyunsaturated fatty acids (LCPUFA), essential constituents of the cell membrane lipids responsible for membrane stability as one of the key factors contributing to the pathophysiology of preeclampsia. We have also reported elevated levels of sFlt-1 in preeclampsia. The present study examines the levels of LCPUFA and their association with sFlt-1 levels in 69 pre-eclamptic women and 40 normotensive women. DHA and omega 3 fatty acid levels were lower (p<0.001) while arachidonic acid and omega 6 fatty acid levels were higher (p<0.05) in preeclamptic women as compared to normotensive women. Maternal plasma sFlt-1 levels were higher (p<0.05) in preeclamptic women and were negatively associated with DHA (p=0.008) and omega 3 fatty acids concentrations (p=0.031). Our results suggest that altered placental LCPUFA may result in altered membrane lipid fatty acid composition leading to increased release of sFlt-1 in circulation.

摘要

我们之前的研究表明，子痫前期妇女体内长链多不饱和脂肪酸（LCPUFA）水平发生改变，而 LCPUFA 是细胞膜脂质的必需成分，负责维持膜的稳定性，是导致子痫前期病理生理学的关键因素之一。我们还报道了子痫前期患者可溶性 fms 样酪氨酸激酶-1（sFlt-1）水平升高。本研究检测了 69 例子痫前期妇女和 40 例正常血压妇女的 LCPUFA 水平及其与 sFlt-1 水平的关系。与正常血压妇女相比，子痫前期妇女的 DHA 和 omega-3 脂肪酸水平较低（p<0.001），而花生四烯酸和 omega-6 脂肪酸水平较高（p<0.05）。子痫前期妇女的母体血浆 sFlt-1 水平较高（p<0.05），与 DHA（p=0.008）和 omega-3 脂肪酸浓度（p=0.031）呈负相关。我们的结果表明，胎盘 LCPUFA 的改变可能导致膜脂质脂肪酸组成改变，从而导致 sFlt-1 在循环中释放增加。