Lefer A M
Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Circ Shock. 1989 Jan;27(1):3-12.
Derivatives of fatty acids (e.g., arachidonic acid) and phospholipids (e.g., platelet activating factor) appear to be important mediators of a significant extent of the pathophysiology of circulatory shock. These lipid mediators are extremely potent substances having a variety of important biological effects contributing to cellular injury. Moreover, prevention of either the formation of these lipid mediators by synthesis inhibitors or blockade of their action via specific receptor antagonism improves these shock states. Also, using sensitive chemical and immunological detection methods, increased amounts of these lipid mediators have been identified in body fluids during shock states. Finally, several of these lipid mediators are linked to the activation of other lipid and non-lipid mediators of shock in a manner which amplifies the actions of the lipid mediators.
脂肪酸衍生物（如花生四烯酸）和磷脂（如血小板活化因子）似乎是循环性休克很大一部分病理生理学的重要介质。这些脂质介质是极具效力的物质，具有多种导致细胞损伤的重要生物学效应。此外，通过合成抑制剂预防这些脂质介质的形成或通过特异性受体拮抗作用阻断其作用，可改善这些休克状态。而且，使用灵敏的化学和免疫检测方法已发现，在休克状态下体液中这些脂质介质的含量增加。最后，其中几种脂质介质与休克的其他脂质和非脂质介质的激活相关联，其方式会放大脂质介质的作用。
