Université de Lyon, UMR 870 Inserm/Insa-Lyon, Villeurbanne, France.
Prostaglandins Leukot Essent Fatty Acids. 2010 Apr-Jun;82(4-6):227-30. doi: 10.1016/j.plefa.2010.02.017. Epub 2010 Mar 6.
Polyunsaturated fatty acids of nutritional value may affect cell functions after their release from cell lipid storage sites, especially phospholipids, and specific oxygenation by cyclooxygenases, lipoxygenases and cytochrome P(450). The end-products, namely prostanoids, leukotrienes, and mono-, di- and tri-hydroxy derivatives exhibit a variety of biological effects, especially on vascular cells, leukocytes and platelets. This paper reviews some results obtained with blood platelets as target cells, showing that various lipoxygenase end-products, mainly mono- and di-hydroxy derivatives, are inhibitors (IC(50) in microM range) of arachidonic acid-induced aggregation either at the cycloxygenase or thromboxane receptor site level.
具有营养价值的多不饱和脂肪酸可能会在从细胞脂质储存位置释放后影响细胞功能，特别是磷脂，以及环氧化酶、脂氧合酶和细胞色素 P(450)的特定氧化作用。终产物，即前列腺素、白三烯和单、二和三羟基衍生物，表现出多种生物效应，特别是对血管细胞、白细胞和血小板。本文综述了一些以血小板为靶细胞获得的结果，表明各种脂氧合酶终产物，主要是单和二羟基衍生物，是抑制物（IC（50）在 microM 范围内），可抑制花生四烯酸诱导的聚集，无论是在环氧化酶还是血栓烷受体部位。
