Spolarich Ann Eshenaur
Division of Dental Public Health and Pediatric Dentistry, Ostrow School of Dentistry of USC, Los Angeles, CA 90089-0641, USA; National Center for Dental Hygiene Research & Practice, Ostrow School of Dentistry of USC, Los Angeles, CA 90089-0641, USA.
J Evid Based Dent Pract. 2014 Jun;14 Suppl:87-94.e1. doi: 10.1016/j.jebdp.2014.04.009. Epub 2014 Apr 4.
Oral adverse drug effects negatively impact oral health, comfort and function.
Patients treated in the oral health care environment take multiple medications, many of which cause oral complications. Dental professionals are challenged with making recommendations to prevent or minimize drug-induced oral disease risks, while reducing symptoms to improve oral health quality of life.
This paper presents a critical analysis of current evidence regarding common oral adverse drug events, and reviews existing clinical practice guidelines based upon findings from published systematic reviews.
There is a lack of sufficient, high quality evidence to support most recommendations for interventions to relieve signs and symptoms of drug-induced oral adverse events. Existing recommendations are largely based on data obtained from observational studies and case reports, and from randomized controlled clinical trials with significant design flaws and potential reporting bias. Outcome measures, especially those related to symptom relief and long-range benefits, are either insufficient or lacking.
Oral adverse drug effects are a common problem, and additional data is needed to support best practices for product recommendations to improve oral health in medicated patients.
药物的口腔不良反应会对口腔健康、舒适度和功能产生负面影响。
在口腔保健环境中接受治疗的患者会服用多种药物，其中许多药物会引发口腔并发症。牙科专业人员面临的挑战是提出建议以预防或尽量降低药物性口腔疾病风险，同时减轻症状以提高口腔健康生活质量。
本文对有关常见口腔药物不良事件的现有证据进行了批判性分析，并根据已发表的系统评价结果对现有临床实践指南进行了综述。
缺乏足够的高质量证据来支持大多数关于缓解药物性口腔不良事件体征和症状的干预措施建议。现有建议很大程度上基于从观察性研究和病例报告以及存在重大设计缺陷和潜在报告偏倚的随机对照临床试验中获得的数据。结局指标，尤其是那些与症状缓解和长期益处相关的指标，要么不充分，要么缺失。
药物的口腔不良反应是一个常见问题，需要更多数据来支持为改善用药患者口腔健康而进行产品推荐的最佳做法。
