Eri1：一种处于多种RNA加工途径交叉点的保守酶。
Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways.
作者信息
Thomas Molly F, L'Etoile Noelle D, Ansel K Mark
机构信息
Department of Microbiology & Immunology, University of California San Francisco, San Francisco, CA 94143, USA; Sandler Asthma Basic Research Center, University of California San Francisco, San Francisco, CA 94143, USA.
Department of Cell & Tissue Biology, University of California San Francisco, San Francisco, CA 94143, USA.
出版信息
Trends Genet. 2014 Jul;30(7):298-307. doi: 10.1016/j.tig.2014.05.003. Epub 2014 Jun 12.
Eri1 is an evolutionarily conserved 3'-5' exoribonuclease that participates in 5.8S rRNA 3' end processing and turnover of replication-dependent histone mRNAs. Over the course of evolution, Eri1 has also been recruited into a variety of conserved and species-specific regulatory small RNA pathways that include endogenous small interfering (si)RNAs and miRNAs. Recent advances in Eri1 biology illustrate the importance of RNA metabolism in epigenetic gene regulation and illuminate common principles and players in RNA biogenesis and turnover. In this review, we highlight Eri1 as a member of a growing class of ribosome- and histone mRNA-associated proteins that have been recruited into divergent RNA metabolic pathways. We summarize recent advances in the understanding of Eri1 function in these pathways and discuss how Eri1 impacts gene expression and physiology in a variety of eukaryotic species. This emerging view highlights the possibility for crosstalk and coregulation of diverse cellular processes regulated by RNA.
Eri1是一种进化上保守的3'-5'外切核糖核酸酶，参与5.8S rRNA 3'末端加工以及复制依赖性组蛋白mRNA的周转。在进化过程中，Eri1还被纳入多种保守的和物种特异性的调节性小RNA途径，包括内源性小干扰（si）RNA和微小RNA（miRNA）。Eri1生物学的最新进展阐明了RNA代谢在表观遗传基因调控中的重要性，并揭示了RNA生物合成和周转中的共同原理及相关因子。在本综述中，我们强调Eri1是一类不断增加的与核糖体和组蛋白mRNA相关的蛋白质成员，这些蛋白质已被纳入不同的RNA代谢途径。我们总结了对Eri1在这些途径中功能理解的最新进展，并讨论了Eri1如何影响多种真核生物物种中的基因表达和生理功能。这种新出现的观点突出了由RNA调节的不同细胞过程之间发生串扰和共同调节的可能性。
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