荷兰肝脏酶水平升高的HIV感染患者中戊型肝炎的患病率
Hepatitis E prevalence among HIV infected patients with elevated liver enzymes in the Netherlands.
作者信息
Hassing R J, van der Eijk A A, Lopes V Baptista, Snijdewind I J, de Man R A, Pas S D, van der Ende M E
机构信息
Department of Internal Medicine and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands; Inspectorate of Health Care, The Hague, The Netherlands.
Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands.
出版信息
J Clin Virol. 2014 Aug;60(4):408-10. doi: 10.1016/j.jcv.2014.05.009. Epub 2014 May 28.
BACKGROUND
In recent years chronic hepatitis E virus (HEV) infections have been reported in immunosuppressed patients, including HIV-positive patients with low CD4 cell counts. Because of delayed anti-HEV seroconversion in patients with CD4 cell count<200 cells/ml it is difficult to draw firm conclusions on HEV-seroprevalence in a population of HIV positive patients.
OBJECTIVES
To determine the HEV seroprevalence in a population of HIV infected patients.
STUDY DESIGN
We retrospectively analysed the HEV prevalence in a population of 256 HIV infected patients with liver enzyme elevations (LEEs), using HEV specific antibody testing and HEV-RNA detection.
RESULTS
Within this cohort we observed a HEV-seroprevalence of 11.7%, without any anti-HEV IgM positive or HEV-RNA positive cases. HEV seropositivity was equally prevalent among different CD4(+) cell count groups.
CONCLUSION
Although HIV infected patients in the Netherlands are at risk of acquiring HEV, the number of acute infections is low and no chronic cases were found.
背景
近年来，免疫功能低下患者中报告了慢性戊型肝炎病毒（HEV）感染，包括CD4细胞计数低的HIV阳性患者。由于CD4细胞计数<200个/毫升的患者抗HEV血清转化延迟，因此难以对HIV阳性患者群体中的HEV血清流行率得出确凿结论。
目的
确定HIV感染患者群体中的HEV血清流行率。
研究设计
我们回顾性分析了256例有肝酶升高（LEE）的HIV感染患者群体中的HEV流行情况，采用HEV特异性抗体检测和HEV-RNA检测。
结果
在该队列中，我们观察到HEV血清流行率为11.7%，没有抗HEV IgM阳性或HEV-RNA阳性病例。HEV血清阳性在不同CD4(+)细胞计数组中同样普遍。
结论
尽管荷兰的HIV感染患者有感染HEV的风险，但急性感染病例数量较少，且未发现慢性病例。
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