Moojen Dirk Jan F, Zwiers Jasper H, Scholtes Vanessa A B, Verheyen Cees C P M, Poolman Rudolf W
Department of Orthopaedic Surgery and Traumatology , Joint Research, Onze Lieve Vrouwe Gasthuis , Amsterdam.
Acta Orthop. 2014 Aug;85(4):383-8. doi: 10.3109/17453674.2014.927729. Epub 2014 Jun 16.
Treatment of an acute total hip arthroplasty (THA) infection aims at control of the infection with retention of the implant by surgical debridement and antibiotic treatment. There is no clear evidence whether a single surgical debridement is sufficient or whether multiple procedures are necessary for optimal treatment.
From a prospective database of patients with acute THA infection, we retrospectively reviewed 68 patients treated in 2 large teaching hospitals. Hospital S used a protocol in which each patient received a single surgical debridement and only additional surgery if infectious symptoms persisted (group S; n = 33). In hospital M, patients always received multiple surgical debridements (group M; n = 35). Both groups received systemic antibiotic treatment. Removal of the implant or persistent infection at follow-up was considered failure of treatment. Mean follow-up of the patients was 5 (2-11) years.
Mean time between implantation and debridement was 19 days. 4 patients in group S were considered failure, as opposed to 10 patients in group M (p = 0.09). 9 patients in group S had additional surgery, which resulted in 3 of the 4 failures. At final follow-up, 30 patients in group S and 33 patients in group M had a good clinical result (p = 0.6).
In patients with acute THA infection, a single debridement with only additional surgery on indication appears to be at least as successful for retention of the primary implant and control of infection as a strategy with multiple surgical debridements.
急性全髋关节置换术(THA)感染的治疗旨在通过手术清创和抗生素治疗来控制感染并保留植入物。目前尚无明确证据表明单次手术清创是否足够,或者是否需要多次手术才能达到最佳治疗效果。
我们从一个急性THA感染患者的前瞻性数据库中,回顾性分析了在两家大型教学医院接受治疗的68例患者。医院S采用的方案是,每位患者接受单次手术清创,只有在感染症状持续时才进行额外手术(S组;n = 33)。在医院M,患者总是接受多次手术清创(M组;n = 35)。两组均接受全身抗生素治疗。随访时植入物取出或持续感染被视为治疗失败。患者的平均随访时间为5(2 - 11)年。
植入与清创之间的平均时间为19天。S组有4例患者被视为治疗失败,而M组为10例(p = 0.09)。S组有9例患者接受了额外手术,其中4例失败中有3例是由此导致的。在最终随访时,S组有30例患者和M组有33例患者临床结果良好(p = 0.6)。
对于急性THA感染患者,单次清创并仅在有指征时进行额外手术,在保留初次植入物和控制感染方面似乎至少与多次手术清创策略一样成功。