Hunter R H F, Gadea J
Sidney Sussex College, Cambridge, UK.
Department of Physiology, University of Murcia, International Excellence Campus for Higher Education and Research (Campus Mare Nostrum); IMIB (Institute for Biomedical Research of Murcia), Spain.
Theriogenology. 2014 Aug;82(3):367-72. doi: 10.1016/j.theriogenology.2014.04.015. Epub 2014 May 9.
This essay proposes that highly localized communication between free and bound spermatozoa in the caudal portion of the oviduct acts to regulate the numbers detaching from the epithelium and progressing to the site of fertilization close to the time of ovulation. Low initial sperm:egg ratios are essential for monospermic fertilization. Liberation of surface macromolecules and metabolic prompting from activated spermatozoa, together with altered patterns of sperm movement and dynamic differences in intracellular Ca(2+) ion status between neighboring sperm cells, would influence the progressive release of spermatozoa from the reservoir in the oviduct isthmus. Different intensities of preovulatory epithelial binding, reflecting a range of states in the sperm surface membranes and associated proteins, would provide a further explanation for a chronologically staggered periovulatory detachment of spermatozoa. Intimate sperm-sperm interactions within the confines of the oviduct isthmus offer a sensitive means of fine-tuning the vanguard of competent male gametes reaching the isthmo-ampullary junction.
本文提出，输卵管尾部游离精子与结合精子之间高度局部化的通讯作用是，在排卵时调节从上皮脱离并向受精部位前进的精子数量。低初始精子与卵子比例对于单精受精至关重要。活化精子释放表面大分子和代谢促进，以及精子运动模式的改变和相邻精子细胞内钙离子状态的动态差异，会影响输卵管峡部储存库中精子的逐步释放。排卵前上皮结合强度不同，反映了精子表面膜和相关蛋白的一系列状态，这将进一步解释排卵前后精子按时间顺序交错脱离的现象。输卵管峡部范围内精子与精子之间的密切相互作用提供了一种微调到达峡部-壶腹交界处的有能力雄配子先锋的敏感方式。
