Rynearson Kevin D, Charrette Brian, Gabriel Christopher, Moreno Jesus, Boerneke Mark A, Dibrov Sergey M, Hermann Thomas
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States.
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States.
Bioorg Med Chem Lett. 2014 Aug 1;24(15):3521-5. doi: 10.1016/j.bmcl.2014.05.088. Epub 2014 Jun 4.
2-Aminobenzoxazoles have been synthesized as ligands for the hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA. The compounds were designed to explore the less basic benzoxazole system as a replacement for the core scaffold in previously discovered benzimidazole viral translation inhibitors. Structure-activity relationships in the target binding of substituted benzoxazole ligands were investigated.
2-氨基苯并恶唑已被合成为丙型肝炎病毒（HCV）内部核糖体进入位点（IRES）RNA的配体。设计这些化合物是为了探索碱性较弱的苯并恶唑体系，以取代先前发现的苯并咪唑病毒翻译抑制剂中的核心支架。研究了取代苯并恶唑配体在靶标结合中的构效关系。
