使用基于亚胺的动态组合化学进行 RNA 配体的模板指导选择。
Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry.
机构信息
Department of Chemistry, Duke University, 124 Science Drive, Durham, NC 27705, USA.
出版信息
Chem Commun (Camb). 2020 Mar 24;56(24):3555-3558. doi: 10.1039/d0cc00266f.
Abstract
This study establishes the applicability of imine-based dynamic combinatorial chemistry to discover non-covalent ligands for RNA targets. We elucidate properties underlying the reactivity of arylamines and demonstrate target-guided amplification of tight binders in an amiloride-based dynamic library.
摘要
本研究确立了基于亚胺的动态组合化学在发现 RNA 靶标非共价配体方面的适用性。我们阐明了芳胺反应性的基础，并在基于阿米洛利的动态文库中证明了靶标引导的紧密结合物的扩增。
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