Saykali Bechara A, El-Sibai Mirvat
Department of Natural Sciences, The Lebanese American University , Beirut , Lebanon.
Cell Commun Adhes. 2014 Aug;21(4):207-12. doi: 10.3109/15419061.2014.923845. Epub 2014 Jun 16.
The occurrence of invadopodia has been, since its characterization, a hallmark of cancerous cell invasion and metastasis. These structures are now the subject of a controversy concerning their cellular function, molecular regulation, and assembly. The terms invadopodia and podosomes have been used interchangeably since their discovery back in 1980. Since then, these phenotypes are now more established and accepted by the scientific community as vital structures for 3D cancer cell motility. Many characteristics relating to invadopodia and podosomes have been elucidated, which might prove these structures as good targets for metastasis treatment. In this review, we briefly review the actin reorganization process needed in most types of cancer cell motility. We also review the important characteristics of invadopodia, including molecular components, assembly, markers, and the signaling pathways, providing a comprehensive model for invadopodia regulation.
自侵袭性伪足被发现以来，它的出现一直是癌细胞侵袭和转移的一个标志。这些结构目前在其细胞功能、分子调控和组装方面存在争议。自1980年被发现以来，侵袭性伪足和小体这两个术语一直被交替使用。从那时起，这些表型现在已被科学界更广泛地认可和接受，成为三维癌细胞运动的重要结构。许多与侵袭性伪足和小体相关的特征已被阐明，这可能证明这些结构是转移治疗的良好靶点。在本综述中，我们简要回顾了大多数类型癌细胞运动所需的肌动蛋白重组过程。我们还回顾了侵袭性伪足的重要特征，包括分子成分、组装、标志物和信号通路，为侵袭性伪足调控提供了一个全面的模型。
