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犬口腔恶性黑色素瘤的非手术治疗:补充替代医学应用的病例研究

Non-surgical treatment of canine oral malignant melanoma: A case study of the application of complementary alternative medicine.

作者信息

Itoh Hiroyasu, Mukaiyama Toshiyuki, Goto Takahiro, Hata Keishi, Azuma Kazuo, Tsuka Takashi, Osaki Tomohiro, Imagawa Tomohiro, Okamoto Yoshiharu

机构信息

Kamo Animal Clinic, Saijyocho, Higashihiroshima, Hiroshima 739-0044, Japan.

Sakamoto Bio Co. Ltd., Yuuwa-Memeki, Akita 010-1233, Japan.

出版信息

Oncol Lett. 2014 Jun;7(6):1829-1830. doi: 10.3892/ol.2014.2041. Epub 2014 Apr 7.

DOI:10.3892/ol.2014.2041
PMID:24932241
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4049709/
Abstract

This report describes a dog with a clinical stage III oral malignant melanoma that was treated with complementary alternative medicine (CAM). The CAM included high temperature hyperthermia, dendritic cell therapy and lupeol injections. Surgery, radiation and chemotherapy were not performed. Two months after the start of treatment, the tumor disappeared and after six months, the follow-up examinations revealed no recurrence or metastasis of the tumor. Quality of life (QOL) of the dog was maintained; therefore, the application of CAM may be an effective treatment for canine oral malignant melanoma. The effective application of CAM has the potential to prolong life and maintain an excellent QOL for pets.

摘要

本报告描述了一只患有临床III期口腔恶性黑色素瘤的犬,接受了补充替代医学(CAM)治疗。CAM包括高温热疗、树突状细胞疗法和羽扇豆醇注射。未进行手术、放疗和化疗。治疗开始两个月后,肿瘤消失,六个月后,随访检查未发现肿瘤复发或转移。该犬的生活质量(QOL)得以维持;因此,CAM的应用可能是犬口腔恶性黑色素瘤的有效治疗方法。CAM的有效应用有可能延长宠物的生命并维持其优异的生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91d0/4049709/3e702d55dc88/OL-07-06-1829-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91d0/4049709/3e702d55dc88/OL-07-06-1829-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91d0/4049709/3e702d55dc88/OL-07-06-1829-g00.jpg

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本文引用的文献

1
Antitumor effects of high-temperature hyperthermia on a glioma rat model.高温热疗对胶质瘤大鼠模型的抗肿瘤作用。
Oncol Lett. 2014 Apr;7(4):1007-1010. doi: 10.3892/ol.2014.1852. Epub 2014 Feb 4.
2
Systemic and local injections of lupeol inhibit tumor growth in a melanoma-bearing mouse model.羽扇豆醇的全身和局部注射可抑制荷黑素瘤小鼠模型中的肿瘤生长。
Biomed Rep. 2013 Jul;1(4):641-645. doi: 10.3892/br.2013.116. Epub 2013 May 28.
3
Differentiation-inducing activity of lupane triterpenes on a mouse melanoma cell line.羽扇豆烷型三萜对小鼠黑色素瘤细胞系的诱导分化活性。
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Canine oral melanoma.犬口腔黑色素瘤
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Lupeol, a fruit and vegetable based triterpene, induces apoptotic death of human pancreatic adenocarcinoma cells via inhibition of Ras signaling pathway.羽扇豆醇是一种基于水果和蔬菜的三萜类化合物,它通过抑制Ras信号通路诱导人胰腺腺癌细胞凋亡。
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A retrospective analysis of 140 dogs with oral melanoma treated with external beam radiation.一项对140只接受外照射放疗的口腔黑色素瘤犬的回顾性分析。
Vet Radiol Ultrasound. 2003 May-Jun;44(3):352-9. doi: 10.1111/j.1740-8261.2003.tb00468.x.
8
Oral malignant melanoma with osteoid formation in a dog.
Vet Pathol. 1999 Jan;36(1):74-6. doi: 10.1354/vp.36-1-74.
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Prognostic criteria for dogs with oral melanoma.犬口腔黑色素瘤的预后标准。
J Am Vet Med Assoc. 1981 Mar 15;178(6):580-2.
10
Canine oral melanoma: comparison of surgery versus surgery plus Corynebacterium parvum.犬口腔黑色素瘤:手术与手术加短小棒状杆菌的比较
Cancer Invest. 1986;4(5):397-402. doi: 10.3109/07357908609017520.