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多形性平滑肌肉瘤中的DNA拷贝数改变：一例报告

DNA copy number alterations in pleomorphic leiomyosarcoma: A case report.

作者信息

Kanamori Masahiko, Yasuda Taketoshi, Nogami Shigeharu, Suzuki Kayo, Hori Takeshi

机构信息

Department of Human Science, University of Toyama, Toyama City, Toyama 930-0194, Japan ; Department of Orthopaedics, University of Toyama, Toyama City, Toyama 930-0194, Japan.

Department of Orthopaedics, University of Toyama, Toyama City, Toyama 930-0194, Japan.

出版信息

Oncol Lett. 2014 Jun;7(6):1847-1850. doi: 10.3892/ol.2014.2030. Epub 2014 Apr 3.

DOI:10.3892/ol.2014.2030
PMID:24932246
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4049769/
Abstract

Pleomorphic leiomyosarcoma (P-LMS) is a rare morphological variant of LMS. The current study presents the cytogenetic data of a P-LMS that arose in the axillary region of a 31-year-old male. The results of array-based comparative genomic hybridization for the primary tumor showed DNA copy number alteration (DCNA) gains of 8ptel, 17ptel and 17q11.2 and losses of 2ptel, 7ptel, 7qtel, 10p15, 12p12-13.1, 13q14.2-14.3, 15q25-26 and Yq11. However, a metastatic lesion showed cytogenetic data different from the primary tumor DCNAs, with only the locus of 17ptel (/) in common between them. These observations add to the spectrum of DCNAs that have been reported in previous cases of LMS and provide novel cytogenetic data.

摘要

多形性平滑肌肉瘤（P-LMS）是平滑肌肉瘤的一种罕见形态学变异型。本研究展示了一名31岁男性腋窝部位发生的P-LMS的细胞遗传学数据。对原发性肿瘤进行基于芯片的比较基因组杂交结果显示，8号染色体短臂末端、17号染色体短臂末端和17q11.2区域存在DNA拷贝数增加（DCNA增益），而2号染色体短臂末端、7号染色体短臂末端、7号染色体长臂末端、10号染色体p15区域、12号染色体p12 - 13.1区域、13号染色体q14.2 - 14.3区域、15号染色体q25 - 26区域以及Y染色体q11区域存在DNA拷贝数减少。然而，一个转移病灶显示出与原发性肿瘤DCNA不同的细胞遗传学数据，它们之间仅在17号染色体短臂末端（/）位点有共同之处。这些观察结果丰富了先前平滑肌肉瘤病例中报道的DCNA谱，并提供了新的细胞遗传学数据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e29/4049769/cf8c5d289966/OL-07-06-1847-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e29/4049769/460315876a6a/OL-07-06-1847-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e29/4049769/7112aadec8e2/OL-07-06-1847-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e29/4049769/fbe9403eadbb/OL-07-06-1847-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e29/4049769/cf8c5d289966/OL-07-06-1847-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e29/4049769/460315876a6a/OL-07-06-1847-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e29/4049769/7112aadec8e2/OL-07-06-1847-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e29/4049769/fbe9403eadbb/OL-07-06-1847-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e29/4049769/cf8c5d289966/OL-07-06-1847-g03.jpg

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本文引用的文献

1
Array-based comparative genomic hybridization for genomic-wide screening of DNA copy number alterations in aggressive bone tumors.基于阵列的比较基因组杂交技术在侵袭性骨肿瘤中进行全基因组 DNA 拷贝数改变的筛选。
J Exp Clin Cancer Res. 2012 Nov 30;31(1):100. doi: 10.1186/1756-9966-31-100.
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Establishment of a new human osteosarcoma cell line, UTOS-1: cytogenetic characterization by array comparative genomic hybridization.一种新的人类骨肉瘤细胞系UTOS-1的建立：通过阵列比较基因组杂交进行细胞遗传学特征分析
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Pleomorphic leiomyosarcoma of the soft parts: a reassessment by histology and immunohistochemistry of pleomorphic soft tissue sarcomas.软组织多形性平滑肌肉瘤：对多形性软组织肉瘤进行组织学和免疫组织化学重新评估
Oncol Rep. 1999 May-Jun;6(3):533-7. doi: 10.3892/or.6.3.533.
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High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays.使用比较基因组杂交微阵列对DNA拷贝数变异进行高分辨率分析。
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DNA copy number changes in development and progression in leiomyosarcomas of soft tissues.软组织平滑肌肉瘤发生发展过程中的DNA拷贝数变化
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Pleomorphic soft tissue myogenic sarcomas of adulthood. A reappraisal in the mid-1990s.成人多形性软组织肌源性肉瘤。20世纪90年代中期的重新评估。
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