Liu Yihong, Liu Yuchen, Wang Pujie, Tian Haoming, Ai Jianzhong, Liu Yangbo, Zhou Yi, Liu Zhongwen, Guo Wenjun, Yang Shenke
Department of Endocrinology and Metabolism, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China ; Diabetic Centre of Control and Prevention, The People's Liberation Army 520 Hospital, Mianyang, Sichuan 621000, P.R. China.
Diabetic Centre of Control and Prevention, The People's Liberation Army 520 Hospital, Mianyang, Sichuan 621000, P.R. China.
Oncol Lett. 2014 Jun;7(6):1857-1862. doi: 10.3892/ol.2014.1998. Epub 2014 Mar 24.
Among stem cells, autologous mesenchymal stem cells (MSCs) are ideal for transplantation by virtue of limited rejection reactions and marked proliferative ability. This study presents a novel method by which MSCs were harvested from the bone marrow of a patient who presented with severe post-traumatic infection and a non-healing skin defect in the hand, secondary to uncontrolled diabetes mellitus (DM). An autologous MSC suspension was injected into the persistent skin defect after stabilizing the blood glucose level and appropriate infection control. During the course of a regular 18-month postoperative follow-up, the patient exhibited immediate recovery with no transplant-associated complications, as well as no evidence of tumorigenicity. Thus, transplantation of autologous MSCs may play a role in the clinical application of stem cells, particularly for treatment of skin defects following surgery in cases of DM and for those caused by various other traumas.
在干细胞中，自体间充质干细胞（MSC）因其排斥反应有限和显著的增殖能力而成为移植的理想选择。本研究提出了一种新方法，从一名患有严重创伤后感染且手部皮肤缺损不愈合的患者骨髓中采集MSC，该患者继发于未控制的糖尿病（DM）。在稳定血糖水平并适当控制感染后，将自体MSC悬液注入持续存在的皮肤缺损处。在术后常规18个月的随访过程中，患者立即康复，未出现与移植相关的并发症，也没有致瘤性证据。因此，自体MSC移植可能在干细胞的临床应用中发挥作用，特别是用于治疗DM患者手术后的皮肤缺损以及由各种其他创伤引起的皮肤缺损。
