Department of Chemistry, Indian Institute of Technology Delhi , Hauz Khas, New Delhi 110016, India.
Biochemistry. 2014 Jul 1;53(25):4081-3. doi: 10.1021/bi500642f. Epub 2014 Jun 20.
Aggregation of α-synuclein has been implicated in Parkinson's disease (PD). While many compounds are known to inhibit α-synuclein aggregation, dissolution of aggregates into their constituent monomers cannot be readily achieved. In this study, using a range of techniques, we have shown that an optimized cocktail of curcumin and β-cyclodextrin, at appreciably low concentrations, not only inhibited aggregation but also broke up the preformed aggregates almost completely. We propose that these compounds exhibit synergy in their action and thus provide us with the exciting prospect of working toward the development of a suitable drug candidate for prevention and treatment of PD.
α-突触核蛋白的聚集与帕金森病（PD）有关。虽然已经有许多化合物被证实可以抑制 α-突触核蛋白的聚集，但却难以将聚集物溶解为其组成单体。在这项研究中，我们使用了一系列技术，表明在相当低的浓度下，优化的姜黄素和β-环糊精混合物不仅可以抑制聚集，还几乎可以完全分解已形成的聚集物。我们提出这些化合物在作用上具有协同性，因此为我们开发合适的预防和治疗 PD 的候选药物提供了令人兴奋的前景。
