弥散加权成像能否用于区分脑脓肿与其他环形增强脑病变？一项荟萃分析。
Can diffusion-weighted imaging be used to differentiate brain abscess from other ring-enhancing brain lesions? A meta-analysis.
机构信息
Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China; Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
出版信息
Clin Radiol. 2014 Sep;69(9):909-15. doi: 10.1016/j.crad.2014.04.012. Epub 2014 Jun 3.
AIM
To explore the role of diffusion-weighted imaging (DWI) in the discrimination of brain abscess from other ring-enhancing brain lesions through meta-analysis.
MATERIALS AND METHODS
The PUMBED, OVID, and China National Knowledge Infrastructure (CNKI) databases, from January 1995 to March 2013, were searched for studies evaluating the diagnostic performance of DWI in the discrimination of brain abscess lesions. Using the data collected, pooled sensitivities and specificities across studies were determined, positive and negative likelihood ratios (LR) were calculated, and summary receiver operating characteristic (SROC) curves were constructed.
RESULTS
A total of 11 studies fulfilled all of the inclusion criteria and were considered for the analysis. The pooled sensitivity values and pooled specificity values including 95% confidence intervals (CI) were 0.95 (0.87-0.98) and 0.94 (0.88-0.97). The pooled positive LR (95% CI) was 4.13(2.55-6.7); the pooled negative LR (95% CI) was 0.01 (0-1.7); and the area under the curve of the symmetric SROC was 0.98.
CONCLUSIONS
DWI has high sensitivity and specificity for the differentiation of brain abscess from other intracranial cystic mass lesions.
目的
通过荟萃分析探讨扩散加权成像（DWI）在鉴别脑脓肿与其他环形增强脑病变中的作用。
材料与方法
检索 PUMBED、OVID 和中国国家知识基础设施（CNKI）数据库，时间范围为 1995 年 1 月至 2013 年 3 月，以评估 DWI 在鉴别脑脓肿病变中的诊断性能的研究。利用收集到的数据，确定了研究间的汇总敏感性和特异性，计算了阳性和阴性似然比（LR），并构建了汇总受试者工作特征（SROC）曲线。
结果
共有 11 项研究符合所有纳入标准，并被纳入分析。汇总敏感性值和汇总特异性值（包括 95%置信区间（CI））分别为 0.95（0.87-0.98）和 0.94（0.88-0.97）。汇总阳性 LR（95%CI）为 4.13（2.55-6.7）；汇总阴性 LR（95%CI）为 0.01（0-1.7）；对称 SROC 的曲线下面积为 0.98。
结论
DWI 对鉴别脑脓肿与其他颅内囊性肿块病变具有较高的敏感性和特异性。
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