自身免疫：调节性B细胞——IL-35和IL-21调节调节因子。
Autoimmunity: regulatory B cells--IL-35 and IL-21 regulate the regulators.
作者信息
Tedder Thomas F, Leonard Warren J
机构信息
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 208921674, USA.
出版信息
Nat Rev Rheumatol. 2014 Aug;10(8):452-3. doi: 10.1038/nrrheum.2014.95. Epub 2014 Jun 17.
Abstract
IL-21 regulates the activity and number of IL-10-producing regulatory B cells (B10 cells) that modulate immune responses and limit diverse autoimmune diseases. A new study demonstrates that IL-35 has a similar function. Identifying regulatory circuits that control B10-cell function in vivo might open the door to future treatments for autoimmune diseases.
摘要
白细胞介素-21调控产生白细胞介素-10的调节性B细胞（B10细胞）的活性和数量，这些细胞可调节免疫反应并限制多种自身免疫性疾病。一项新研究表明，白细胞介素-35具有类似功能。确定体内控制B10细胞功能的调节回路可能为未来自身免疫性疾病的治疗打开大门。
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IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases.产生白细胞介素-35的B细胞是自身免疫性疾病和感染性疾病期间免疫的关键调节因子。
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