提高 OCT 成像检测青光眼损伤的应用。
On improving the use of OCT imaging for detecting glaucomatous damage.
机构信息
Department of Psychology, Columbia University, New York, New York, USA Department of Ophthalmology, Columbia University, New York, New York, USA.
Department of Psychology, Columbia University, New York, New York, USA Department of Neurobiology and Behavior, Columbia University, New York, New York, USA.
出版信息
Br J Ophthalmol. 2014 Jul;98 Suppl 2(Suppl 2):ii1-9. doi: 10.1136/bjophthalmol-2014-305156.
AIMS
To describe two approaches for improving the detection of glaucomatous damage seen with optical coherence tomography (OCT).
METHODS
The two approaches described were: one, a visual analysis of the high-quality OCT circle scans and two, a comparison of local visual field sensitivity loss to local OCT retinal ganglion cell plus inner plexiform (RGC+) and retinal nerve fibre layer (RNFL) thinning. OCT images were obtained from glaucoma patients and suspects using a spectral domain OCT machine and commercially available scanning protocols. A high-quality peripapillary circle scan (average of 50), a three-dimensional (3D) scan of the optic disc, and a 3D scan of the macula were obtained. RGC+ and RNFL thickness and probability plots were generated from the 3D scans.
RESULTS
A close visual analysis of a high-quality circle scan can help avoid both false positive and false negative errors. Similarly, to avoid these errors, the location of abnormal visual field points should be compared to regions of abnormal RGC+ and RNFL thickness.
CONCLUSIONS
To improve the sensitivity and specificity of OCT imaging, high-quality images should be visually scrutinised and topographical information from visual fields and OCT scans combined.
目的
描述两种提高光学相干断层扫描（OCT）检测青光眼损害的方法。
方法
描述的两种方法是：一，对高质量 OCT 环形扫描进行视觉分析；二，将局部视野灵敏度损失与局部 OCT 视网膜神经节细胞加内丛状层（RGC+）和视网膜神经纤维层（RNFL）变薄进行比较。使用光谱域 OCT 机器和商业上可用的扫描方案从青光眼患者和疑似患者中获取 OCT 图像。获得了高质量的视盘周边环形扫描（平均 50 次）、视神经盘的三维（3D）扫描和黄斑的 3D 扫描。从 3D 扫描生成 RGC+和 RNFL 厚度和概率图。
结果
对高质量环形扫描进行仔细的视觉分析有助于避免假阳性和假阴性错误。同样，为了避免这些错误，应将异常视野点的位置与异常 RGC+和 RNFL 厚度的区域进行比较。
结论
为了提高 OCT 成像的灵敏度和特异性，应仔细观察高质量图像，并结合视野和 OCT 扫描的地形信息。
Zotero 插件