Abel Gary R, Cao Blessing Huynh, Hein Jason E, Ye Tao
Chemistry and Chemical Biology, School of Natural Sciences, University of California, 5200 N. Lake Rd., Merced, CA 95343, USA.
Chem Commun (Camb). 2014 Aug 4;50(60):8131-3. doi: 10.1039/c4cc02900c.
We present a novel method that covalently and sequence-specifically attaches long DNA molecules to a surface that is compatible with high-resolution atomic force microscopy (AFM) imaging. Surfaces prepared with this approach are ideally suited for performing biophysical experiments on single DNA molecules.
我们提出了一种新方法，该方法能将长链DNA分子以共价且序列特异性的方式连接到与高分辨率原子力显微镜（AFM）成像兼容的表面上。用这种方法制备的表面非常适合对单个DNA分子进行生物物理实验。
