在未经治疗的肥胖高血压患者中，血清尿酸升高与血管紧张素原有关。
Elevated serum uric acid is associated with angiotensinogen in obese patients with untreated hypertension.
作者信息
Zhang Junxia, Zhang Yuping, Deng Wuquan, Chen Bing
机构信息
Department of Endocrinology and Metabolism, Southwest Hospital, Third Military Medical University, Chongqing, China.
出版信息
J Clin Hypertens (Greenwich). 2014 Aug;16(8):569-74. doi: 10.1111/jch.12353. Epub 2014 Jun 16.
Abstract
This study investigated the correlation between elevated serum uric acid (SUA) and angiotensinogen in obesity patients with hypertension. A total of 162 obese and 162 nonobese men with hypertension were recruited in this study. Plasma angiotensinogen levels were measured by enzyme-linked immunosorbent assay. Fasting insulin (FINS) was evaluated by radioimmunoassay. Compared with nonobese patients, obese patients exhibited higher levels of angiotensinogen, FINS, and homeostasis model assessment index-insulin resistance (HOMA-IR) (P<.001 for all). Moreover, these indexes significantly increased in obese patients in the highest tertile of SUA when compared with those in the lowest tertile of SUA (P<.001, P=.002, P=.007, respectively). In the obese group, SUA levels were significantly related to angiotensinogen, FINS, and HOMA-IR, respectively. Furthermore, it was demonstrated that obesity × uric acid was an independent contributor to angiotensinogen (β=0.257, P<.001). In conclusion, elevated SUA is strongly related to angiotensinogen in an obesity-dependent manner in hypertension.
摘要
本研究调查了肥胖高血压患者血清尿酸（SUA）升高与血管紧张素原之间的相关性。本研究共纳入了162名肥胖高血压男性和162名非肥胖高血压男性。采用酶联免疫吸附测定法检测血浆血管紧张素原水平。采用放射免疫测定法评估空腹胰岛素（FINS）。与非肥胖患者相比，肥胖患者的血管紧张素原、FINS和稳态模型评估指数-胰岛素抵抗（HOMA-IR）水平更高（所有P均<0.001）。此外，与SUA最低三分位数的肥胖患者相比，SUA最高三分位数的肥胖患者这些指标显著升高（分别为P<0.001、P=0.002、P=0.007）。在肥胖组中，SUA水平分别与血管紧张素原、FINS和HOMA-IR显著相关。此外，研究表明肥胖×尿酸是血管紧张素原的独立影响因素（β=0.257，P<0.001）。总之，在高血压患者中，SUA升高以肥胖依赖的方式与血管紧张素原密切相关。
相似文献
1
Elevated serum uric acid is associated with angiotensinogen in obese patients with untreated hypertension.在未经治疗的肥胖高血压患者中，血清尿酸升高与血管紧张素原有关。
J Clin Hypertens (Greenwich). 2014 Aug;16(8):569-74. doi: 10.1111/jch.12353. Epub 2014 Jun 16.
2
Obesity-Induced Insulin Resistance Is Mediated by High Uric Acid in Obese Children and Adolescents.肥胖诱导的胰岛素抵抗是由肥胖儿童和青少年体内尿酸水平升高引起的。
Front Endocrinol (Lausanne). 2021 Dec 3;12:773820. doi: 10.3389/fendo.2021.773820. eCollection 2021.
3
The application value of serum 25(OH)D3, uric acid, triglyceride, and homeostasis model assessment of insulin resistance in male patients with hyperuricemia combined with hypogonadism.血清 25(OH)D3、尿酸、甘油三酯及胰岛素抵抗稳态模型评估在男性高尿酸血症合并性腺功能减退症患者中的应用价值。
BMC Endocr Disord. 2021 May 22;21(1):102. doi: 10.1186/s12902-021-00765-y.
4
Hypertension and obesity: correlates with renin-angiotensin-aldosterone system and uric acid.高血压与肥胖：与肾素-血管紧张素-醛固酮系统及尿酸的相关性
J Clin Hypertens (Greenwich). 2014 Aug;16(8):559-60. doi: 10.1111/jch.12356. Epub 2014 Jun 23.
5
Ghrelin PYY 3-36 serum changes in left ventricular hypertrophic, insulin-resistant, hypertensive obese patients.瘦素-胰高血糖素样肽 3-36 血清在左心室肥厚、胰岛素抵抗、高血压肥胖患者中的变化。
Obes Facts. 2011;4(5):386-92. doi: 10.1159/000334198. Epub 2011 Oct 21.
6
Plasma angiotensinogen concentrations in obese patients.肥胖患者的血浆血管紧张素原浓度。
Am J Hypertens. 1997 Jun;10(6):629-33. doi: 10.1016/s0895-7061(97)00053-8.
7
[Correlation Between Testosterone and Metabolic Index in Male Patients with Type 2 Diabetes Mellitus].2型糖尿病男性患者睾酮与代谢指标的相关性
Sichuan Da Xue Xue Bao Yi Xue Ban. 2018 Mar;49(2):235-238.
8
A comparative research on obesity hypertension by the comparisons and associations between waist circumference, body mass index with systolic and diastolic blood pressure, and the clinical laboratory data between four special Chinese adult groups.四种特殊中国成年人群腰围、体质指数与收缩压和舒张压的比较和关联，以及临床实验室数据与肥胖高血压的对比研究。
Clin Exp Hypertens. 2018;40(1):16-21. doi: 10.1080/10641963.2017.1281940. Epub 2017 Oct 30.
9
Bariatric surgery in severely obese adolescents improves major comorbidities including hyperuricemia.肥胖青少年的减重手术可改善多种主要合并症，包括高尿酸血症。
Metabolism. 2014 Feb;63(2):242-9. doi: 10.1016/j.metabol.2013.11.012. Epub 2013 Nov 22.
10
Waist circumference, ghrelin and selected adipose tissue-derived adipokines as predictors of insulin resistance in obese patients: preliminary results.腰围、胃饥饿素和部分脂肪组织来源的脂肪因子作为肥胖患者胰岛素抵抗的预测指标：初步研究结果。
Med Sci Monit. 2011 Nov;17(11):PR13-18. doi: 10.12659/msm.882030.
引用本文的文献
1
Association of obesity with hyperuricaemia among HIV-positive patients on antiretroviral therapy in South-Western Uganda.乌干达西南部接受抗逆转录病毒治疗的HIV阳性患者中肥胖与高尿酸血症的关联
Afr J Lab Med. 2025 Feb 19;14(1):2565. doi: 10.4102/ajlm.v14i1.2565. eCollection 2025.
2
Severe Hypouricemia Impairs Endothelium-Dependent Vasodilatation and Reduces Blood Pressure in Healthy Young Men: A Randomized, Placebo-Controlled, and Crossover Study.严重低尿酸血症可损害健康年轻男性的血管内皮依赖性血管舒张功能并降低血压：一项随机、安慰剂对照、交叉研究。
J Am Heart Assoc. 2019 Dec 3;8(23):e013130. doi: 10.1161/JAHA.119.013130. Epub 2019 Nov 22.
3
What is the most important determinant of cardiometabolic risk in 60-65-year-old subjects: physical activity-related behaviours, overall energy expenditure or occupational status? A cross-sectional study in three populations with different employment status in Poland.在60至65岁人群中，心脏代谢风险的最重要决定因素是什么：与身体活动相关的行为、总能量消耗还是职业状况？一项针对波兰三种不同就业状况人群的横断面研究。
BMJ Open. 2019 Jul 30;9(7):e025905. doi: 10.1136/bmjopen-2018-025905.
4
Prevalence of hyperuricemia and the relationship between serum uric acid and obesity: A study on Bangladeshi adults.高尿酸血症的患病率及血尿酸与肥胖的关系：孟加拉国成年人研究。
PLoS One. 2018 Nov 1;13(11):e0206850. doi: 10.1371/journal.pone.0206850. eCollection 2018.
5
Relation of serum uric acid to an exaggerated systolic blood pressure response to exercise testing in men with normotension.血清尿酸与血压正常男性运动试验中收缩压反应过度的关系。
J Clin Hypertens (Greenwich). 2018 Mar;20(3):551-556. doi: 10.1111/jch.13219. Epub 2018 Feb 19.
6
Overweight modifies the longitudinal association between uric acid and some components of the metabolic syndrome: The Tromsø Study.超重改变了尿酸与代谢综合征某些组分之间的纵向关联：特罗姆瑟研究。
BMC Cardiovasc Disord. 2016 May 10;16:85. doi: 10.1186/s12872-016-0265-8.
7
Effect of Febuxostat, a Xanthine Oxidase Inhibitor, on Cardiovascular Risk in Hyperuricemic Patients with Hypertension: A Prospective, Open-label, Pilot Study.黄嘌呤氧化酶抑制剂非布司他对高血压合并高尿酸血症患者心血管风险的影响：一项前瞻性、开放标签的试点研究。
Clin Drug Investig. 2015 Dec;35(12):823-31. doi: 10.1007/s40261-015-0349-8.
8
Preterm Birth Is Associated with Higher Uric Acid Levels in Adolescents.早产与青少年尿酸水平升高有关。
J Pediatr. 2015 Jul;167(1):76-80. doi: 10.1016/j.jpeds.2015.03.043. Epub 2015 Apr 11.
9
Hypertension and obesity: correlates with renin-angiotensin-aldosterone system and uric acid.高血压与肥胖：与肾素-血管紧张素-醛固酮系统及尿酸的相关性
J Clin Hypertens (Greenwich). 2014 Aug;16(8):559-60. doi: 10.1111/jch.12356. Epub 2014 Jun 23.
本文引用的文献
1
Prevalence of hyperuricemia and its related risk factors in healthy adults from Northern and Northeastern Chinese provinces.中国北方和东北地区健康成年人高尿酸血症的患病率及其相关危险因素
BMC Public Health. 2013 Jul 17;13:664. doi: 10.1186/1471-2458-13-664.
2
Adipocyte deficiency of angiotensinogen prevents obesity-induced hypertension in male mice.脂肪细胞血管紧张素原缺乏可预防雄性肥胖诱导的高血压。
Hypertension. 2012 Dec;60(6):1524-30. doi: 10.1161/HYPERTENSIONAHA.112.192690. Epub 2012 Oct 29.
3
Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice.脂肪细胞特异性血管紧张素原缺乏症可降低小鼠血浆血管紧张素原浓度和收缩压。
Am J Physiol Regul Integr Comp Physiol. 2012 Jan 15;302(2):R244-51. doi: 10.1152/ajpregu.00323.2011. Epub 2011 Nov 9.
4
The renin-angiotensin system: a link between obesity, inflammation and insulin resistance.肾素-血管紧张素系统：肥胖、炎症和胰岛素抵抗之间的联系。
Obes Rev. 2012 Feb;13(2):136-49. doi: 10.1111/j.1467-789X.2011.00942.x. Epub 2011 Oct 31.
5
Uric acid and hypertension.尿酸与高血压。
Semin Nephrol. 2011 Sep;31(5):441-6. doi: 10.1016/j.semnephrol.2011.08.008.
6
Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome.代谢综合征小鼠模型脂肪组织促炎内分泌失衡的中介物：高尿酸血症。
Diabetes. 2011 Apr;60(4):1258-69. doi: 10.2337/db10-0916. Epub 2011 Feb 23.
7
Soluble uric acid increases intracellular calcium through an angiotensin II-dependent mechanism in immortalized human mesangial cells.可溶性尿酸通过血管紧张素 II 依赖机制增加永生化人肾小球系膜细胞内的钙。
Exp Biol Med (Maywood). 2010 Jul;235(7):825-32. doi: 10.1258/ebm.2010.010007.
8
9
Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response.过量果糖摄入可诱导健康成年男性出现代谢综合征特征：尿酸在高血压反应中的作用。
Int J Obes (Lond). 2010 Mar;34(3):454-61. doi: 10.1038/ijo.2009.259. Epub 2009 Dec 22.
10
Uric acid and left ventricular hypertrophy in Japanese men.日本男性的尿酸与左心室肥厚
Circ J. 2009 Apr;73(4):667-72. doi: 10.1253/circj.cj-08-0626. Epub 2009 Feb 19.
Zotero 插件