Zhang Junxia, Zhang Yuping, Deng Wuquan, Chen Bing
Department of Endocrinology and Metabolism, Southwest Hospital, Third Military Medical University, Chongqing, China.
J Clin Hypertens (Greenwich). 2014 Aug;16(8):569-74. doi: 10.1111/jch.12353. Epub 2014 Jun 16.
This study investigated the correlation between elevated serum uric acid (SUA) and angiotensinogen in obesity patients with hypertension. A total of 162 obese and 162 nonobese men with hypertension were recruited in this study. Plasma angiotensinogen levels were measured by enzyme-linked immunosorbent assay. Fasting insulin (FINS) was evaluated by radioimmunoassay. Compared with nonobese patients, obese patients exhibited higher levels of angiotensinogen, FINS, and homeostasis model assessment index-insulin resistance (HOMA-IR) (P<.001 for all). Moreover, these indexes significantly increased in obese patients in the highest tertile of SUA when compared with those in the lowest tertile of SUA (P<.001, P=.002, P=.007, respectively). In the obese group, SUA levels were significantly related to angiotensinogen, FINS, and HOMA-IR, respectively. Furthermore, it was demonstrated that obesity × uric acid was an independent contributor to angiotensinogen (β=0.257, P<.001). In conclusion, elevated SUA is strongly related to angiotensinogen in an obesity-dependent manner in hypertension.
本研究调查了肥胖高血压患者血清尿酸（SUA）升高与血管紧张素原之间的相关性。本研究共纳入了162名肥胖高血压男性和162名非肥胖高血压男性。采用酶联免疫吸附测定法检测血浆血管紧张素原水平。采用放射免疫测定法评估空腹胰岛素（FINS）。与非肥胖患者相比，肥胖患者的血管紧张素原、FINS和稳态模型评估指数-胰岛素抵抗（HOMA-IR）水平更高（所有P均<0.001）。此外，与SUA最低三分位数的肥胖患者相比，SUA最高三分位数的肥胖患者这些指标显著升高（分别为P<0.001、P=0.002、P=0.007）。在肥胖组中，SUA水平分别与血管紧张素原、FINS和HOMA-IR显著相关。此外，研究表明肥胖×尿酸是血管紧张素原的独立影响因素（β=0.257，P<0.001）。总之，在高血压患者中，SUA升高以肥胖依赖的方式与血管紧张素原密切相关。
